Laura M. Koehly

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Spanning nearly sixty years of research, statistical network analysis has passed through (at least) two generations of researchers and models. Beginning in the late 1930’s, the first generation of research dealt with the distribution of various network statistics, under a variety of null models. The second generation, beginning in the 1970’s and continuing(More)
We argue that social networks can be modeled as the outcome of processes that occur in overlapping local regions of the network, termed local social neighborhoods. Each neighborhood is conceived as a possible site of interaction and corresponds to a subset of possible network ties. In this paper, we discuss hypotheses about the form of these neighborhoods,(More)
Hereditary cancers are relational diseases. A primary focus of research in the past has been the biological relations that exist within the families and how genes are passed along family lines. However, hereditary cancers are relational in a psychosocial sense, as well. They can impact communication relationships within a family, as well as support(More)
Little is known about how hereditary nonpolyposis colon cancer (HNPCC) genetic counseling and testing information is communicated within at-risk families. This article describes findings from a qualitative study of 39 adult members from five families with known HNPCC-predisposing mutations. We evaluated how information from HNPCC genetic counseling and(More)
Despite the quickening momentum of genomic discovery, the communication, behavioral, and social sciences research needed for translating this discovery into public health applications has lagged behind. The National Human Genome Research Institute held a 2-day workshop in October 2008 convening an interdisciplinary group of scientists to recommend(More)
A "bidirectional gene pair" comprises two adjacent genes whose transcription start sites are neighboring and directed away from each other. The intervening regulatory region is called a "bidirectional promoter." These promoters are often associated with genes that function in DNA repair, with the potential to participate in the development of cancer. No(More)
OBJECTIVES The emotional effects of genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC) provided within a counseling program were assessed among 253 individuals. METHODS Assessments were scheduled at baseline before testing, and again after 6 and 12 months post-test. Negative emotional reactions were evaluated using the Revised Impact of(More)
OBJECTIVES Given the importance of the dissemination of accurate family history to assess disease risk, we characterized the gatherers, disseminators, and blockers of health information within families at high genetic risk of cancer. METHODS A total of 5466 personal network members of 183 female participants of the Breast Imaging Study from 124 families(More)
This study evaluates the extent to which psychological adaptation (validated measures of depressive symptoms, anxiety, and test-specific distress) after genetic susceptibility testing is influenced by changes in beliefs about Alzheimer's disease (AD) and sharing of test results with others. Adult children of AD patients (N=269) from a randomized clinical(More)
PURPOSE To evaluate whether influence from social network members is associated with motivation to change dietary and physical activity behaviors. DESIGN Baseline assessment followed by mailing of family health history-based personalized messages (2 weeks) and follow-up assessment (3 months). SETTING Families from an ongoing population-based cohort in(More)