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- Shan Ping Yu, C. H. Yeh, +7 authors Dennis W. Choi
- Science
- 1997
Apoptosis of mouse neocortical neurons induced by serum deprivation or by staurosporine was associated with an early enhancement of delayed rectifier (IK) current and loss of total intracellular K+.… (More)
- M Margarita Behrens, Sameh S Ali, +4 authors Laura L. Dugan
- Science
- 2007
Abuse of the dissociative anesthetic ketamine can lead to a syndrome indistinguishable from schizophrenia. In animals, repetitive exposure to this N-methyl-d-aspartate-receptor antagonist induces the… (More)
- Julie Lotharius, Laura L. Dugan, Karen L O'Malley
- The Journal of neuroscience : the official…
- 1999
Oxidative stress is thought to contribute to dopaminergic cell death in Parkinson's disease (PD). The neurotoxin 6-hydroxydopamine (6-OHDA), which is easily oxidized to reactive oxygen species (ROS),… (More)
- Laura L. Dugan, Stefano L Sensi, +5 authors Dennis W. Choi
- The Journal of neuroscience : the official…
- 1995
Increasing evidence suggests that glutamate neurotoxicity is partly mediated by reactive oxygen species, formed as a consequence of several processes, including arachidonic acid metabolism and nitric… (More)
- Kevin K. Ohlemiller, Jesse S. Wright, Laura L. Dugan
- Audiology & neuro-otology
- 1999
Reactive oxygen species (ROS) have been implicated in a growing number of neurological disease states, from acute traumatic injury to neurodegenerative conditions such as Alzheimer's disease.… (More)
- Laura L. Dugan, Joong Soo Kim, +4 authors David H Gutmann
- The Journal of biological chemistry
- 1999
Mitogen-activated protein kinase (MAPK) activation provides cell type-specific signals important for cellular differentiation, proliferation, and survival. Cyclic AMP (cAMP) has divergent effects on… (More)
- Laura L. Dugan, Dorothy M. Turetsky, +7 authors Thomas H S Lin
- Proceedings of the National Academy of Sciences…
- 1997
Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical… (More)
- Laura L. Dugan, Young-Hyun You, +19 authors Kumar Sharma
- The Journal of clinical investigation
- 2013
Diabetic microvascular complications have been considered to be mediated by a glucose-driven increase in mitochondrial superoxide anion production. Here, we report that superoxide production was… (More)
- Laura L. Dugan, Vincent M. Bruno, Shanti Amagasu, Rona G. Giffard
- The Journal of neuroscience : the official…
- 1995
We have developed "pure" neuronal cultures (< 1% astrocytes) from mouse neocortex to study the effect of glial cells on the response of neurons to injury. Cortical neurons were found to require… (More)
- M Margarita Behrens, Sameh S Ali, Laura L. Dugan
- The Journal of neuroscience : the official…
- 2008
Adult exposure to NMDA receptor antagonists, such as ketamine, produces psychosis in humans, and exacerbates symptoms in schizophrenic patients. We recently showed that ketamine activates the innate… (More)