Laura L. Custer

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Despite the wealth of different actin structures formed, only two actin nucleation factors are well established in vertebrates: the Arp2/3 complex and formins. Here, we describe a further nucleator, cordon-bleu (Cobl). Cobl is a brain-enriched protein using three Wiskott-Aldrich syndrome protein homology 2 (WH2) domains for actin binding. Cobl promotes(More)
Binary quantitative structure-activity relationship (QSAR) models are developed to classify a data set of 334 aromatic and secondary amine compounds as genotoxic or nongenotoxic based on information calculated solely from chemical structure. Genotoxic endpoints for each compound were determined using the SOS Chromotest in both the presence and absence of an(More)
  • Citation Zeiger, Errol, Bhaskar Gollapudi, Marilyn J Aardema, Scott Auerbach, Darrell Boverhof +20 others
  • 2015
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract * Correspondence to: Errol
genes that control motor neuron induction, subtype identity, and target specificity. Mice were mutagenized with ENU and out-crossed to an HB9-GFP transgenic reporter line that expresses GFP in spinal motor neurons and their axons. Litters were analyzed by fluorescence microscopy for recessive mutations that affect motor neuron induction and motor axon(More)
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