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Current studies are inconclusive regarding specific patterns of gender differences in age-associated hearing loss. This paper presents results from the largest and longest longitudinal study reported to date of changes in pure-tone hearing thresholds in men and women screened for otological disorders and noise-induced hearing loss. Since 1965, the Baltimore(More)
The standard linearization of a binary quadratic program yields an equivalent reformulation as an integer linear program, but the resulting LP-bounds are very weak in general. We concentrate on applications where the underlying linear problem is tractable and exploit the fact that, in this case, the optimization problem is still tractable in the presence of(More)
This paper describes an innovative multiagent system called SAVES with the goal of conserving energy in commercial buildings. We specifically focus on an application to be deployed in an existing university building that provides several key novelties: (i) jointly performed with the university facility management team, SAVES is based on actual occupant(More)
Recent years have seen a rise of interest in the deployment of mul-tiagent systems in energy domains that inherently have uncertain and dynamic environments with limited resources. In such domains , the key challenge is to minimize the energy consumption while satisfying the comfort level of occupants in the buildings under uncertainty (regarding agent(More)
In lower or simple species, such as worms and flies, disruption of the insulin-like growth factor (IGF)-1 and the insulin signaling pathways has been shown to increase lifespan. In rodents, however, growth hormone (GH) regulates IGF-1 levels in serum and tissues and can modulate lifespan via/or independent of IGF-1. Rodent models, where the GH/IGF-1 axis(More)
The primary consumers of building energy are heating, cooling, ventilation, and lighting systems, which maintain occupant comfort, and electronics and appliances that enable occupant functionality. The optimization of building energy is therefore a complex problem highly dependent on unique building and environmental conditions as well as on time dependent(More)
Across plants, leaves exhibit profound diversity in shape. As a single leaf expands, its shape is in constant flux. Plants may also produce leaves with different shapes at successive nodes. In addition, leaf shape varies among individuals, populations and species as a result of evolutionary processes and environmental influences. Because leaf shape can vary(More)