Laura Jacox

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The mouth arises from the extreme anterior domain (EAD), a region where the ectoderm and endoderm are directly juxtaposed. Here, we identify a "pre-mouth array" in Xenopus that forms soon after the cranial neural crest has migrated to lie on either side of the EAD. Initially, EAD ectoderm comprises a wide and short epithelial mass that becomes narrow and(More)
Graphical Abstract Highlights d A Xenopus pre-mouth cell array splits down the midline to surround the oral opening d The pre-mouth array forms by convergent extension of EAD ectoderm d EAD morphogenesis is directed by adjacent cranial neural crest d Wnt/PCP signaling is necessary and sufficient to elicit EAD convergent extension In Brief Jacox et al.(More)
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