Laura J van T Veer

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Li-Fraumeni syndrome (LFS) is an autosomal-dominant condition characterized by early-onset sarcoma, breast cancer and other specific tumour types. In most LFS kindreds germline TP53 mutations have been identified. In general, TP53 germline mutations are not associated with late-onset common cancers. We encountered a large kindred in which a wide spectrum of(More)
(1998) Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. (1999) Disruption of p53 in human cancer cells alters the responses to therapeutic agents. (2000) Association of tumour site(More)
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