Laura H Hogan

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The 'hygiene hypothesis' has been proposed to explain apparent increases in autoimmune disease and allergy in areas of the world with improved health care and sanitation. This hypothesis proposes that the lack of serious childhood infections impairs development of an appropriately educated immune response. Imbalance of Th1 and Th2 responses and lack of(More)
Virulence factors of medically important fungi. INTRODUCTION Central to a review of virulence factors is the question, " What is a virulence factor? " Strictly and simply defined, it is any factor that a fungus possesses that increases its virulence in the host. Many virulence factors are of such obvious importance that they are often taken for granted. For(More)
The effect of secondary infections on CD4 T-cell-regulated chronic granulomatous inflammation is not well understood. Here, we have investigated the effect of an acute viral infection on the cellular composition and bacterial protection in Mycobacterium bovis strain bacille Calmette-Guérin (BCG)-induced granulomas using an immunocompetent and a partially(More)
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