Laura Gianotti

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Patients undergoing pancreaticoduodenectomy (PD) often require postoperative artificial nutrition. This trial was undertaken to evaluate whether the route of administration and the composition of the postoperative nutritional support could affect the immunometabolic response and outcome. A prospective, randomized trial was carried out in 212 subjects who(More)
BACKGROUND Although current opinion favours the use of enteral over parenteral nutrition, the clinical benefits of early postoperative nutrition in patients undergoing elective surgery have never been clearly shown. We aimed to test the hypothesis that postoperative enteral nutrition is better (fewer postoperative complications) than parenteral nutrition(More)
PURPOSE The aim of this study was to evaluate the reliability of intraoperative laser-Doppler measurements in predicting the occurrence of anastomotic leak in patients with colorectal cancer undergoing stapled straight anastomosis to the rectum. METHODS A prospective study was undertaken on 55 patients with rectal cancer or distal sigmoid cancer(More)
HYPOTHESIS Perioperative administration of a supplemented enteral formula may reduce the rate of postoperative infections. DESIGN Prospective, randomized, double-blind clinical trial. SETTING Department of surgery at a university hospital. PATIENTS Two hundred six patients with neoplasm of colorectum, stomach, or pancreas. INTERVENTION Patients were(More)
AIM To investigate the effect of early postoperative enteral nutrition enriched with arginine, RNA and omega-3 fatty acids on immunological and nutritional variables after elective curative operations for gastric or pancreatic cancer. DESIGN Randomised controlled trial. SETTING University hospital, Italy. SUBJECTS 78 Consecutive patients who were to(More)
GH-releasing peptides (GHRPs) are synthetic, nonnatural molecules that strongly stimulate GH secretion, but also slightly increase PRL, ACTH, and cortisol levels in man. To investigate the mechanism underlying the ACTH- and cortisol-releasing activity of GHRPs in man, we compared the ACTH- and cortisol-releasing activity of Hexarelin (HEX; 2.0(More)
OBJECTIVE To study the effect of the route of delivery and formulation of postoperative nutritional support on host defense, protein metabolism, infectious complications, and outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of Surgery at a university hospital. PATIENTS Two hundred sixty candidates for pancreaticoduodenectomy(More)
In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml)(More)
BACKGROUND Glutamine has been shown to be an important dietary component for the maintenance of gut metabolism. The purpose of this study was to assess the potential benefit of glutamine-enriched diets on experimental gut-derived sepsis. METHODS BALB/c mice were fed either 2% glutamine-supplemented or 1% glycine-supplemented (near-isonitrogenous control)(More)
OBJECTIVE To evaluate the impact of the route of administration of artificial nutrition and the composition of the diet on outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of surgery, university hospital. PATIENTS One hundred sixty-six consecutive patients undergoing curative surgery for gastric or pancreatic cancer. (More)