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AIM To investigate the effect of early postoperative enteral nutrition enriched with arginine, RNA and omega-3 fatty acids on immunological and nutritional variables after elective curative operations for gastric or pancreatic cancer. DESIGN Randomised controlled trial. SETTING University hospital, Italy. SUBJECTS 78 Consecutive patients who were to(More)
BACKGROUND Although current opinion favours the use of enteral over parenteral nutrition, the clinical benefits of early postoperative nutrition in patients undergoing elective surgery have never been clearly shown. We aimed to test the hypothesis that postoperative enteral nutrition is better (fewer postoperative complications) than parenteral nutrition(More)
OBJECTIVE To study the effect of the route of delivery and formulation of postoperative nutritional support on host defense, protein metabolism, infectious complications, and outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of Surgery at a university hospital. PATIENTS Two hundred sixty candidates for pancreaticoduodenectomy(More)
Patients undergoing pancreaticoduodenectomy (PD) often require postoperative artificial nutrition. This trial was undertaken to evaluate whether the route of administration and the composition of the postoperative nutritional support could affect the immunometabolic response and outcome. A prospective, randomized trial was carried out in 212 subjects who(More)
OBJECTIVE To evaluate the impact of the route of administration of artificial nutrition and the composition of the diet on outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of surgery, university hospital. PATIENTS One hundred sixty-six consecutive patients undergoing curative surgery for gastric or pancreatic cancer. (More)
GH-releasing peptides (GHRPs) are synthetic, nonnatural molecules that strongly stimulate GH secretion, but also slightly increase PRL, ACTH, and cortisol levels in man. To investigate the mechanism underlying the ACTH- and cortisol-releasing activity of GHRPs in man, we compared the ACTH- and cortisol-releasing activity of Hexarelin (HEX; 2.0(More)
The activity of the GH-IGF-I axis undergoes an age-related reduction and in the elderly both spontaneous GH secretion and IGF-I levels are frequently low overlapping with those usually recorded in GH deficient patients. Hypoactivity of the GH-IGF-I axis could explain age-related changes in body composition, function and metabolism, as also indicated by(More)
Alprazolam (ALP), a benzodiazepine that activates gamma-aminobutyric acid-ergic receptors, inhibits the activity of hypothalamo-pituitary-adrenal (HPA) axis, probably via inhibition of hypothalamic CRH and/or arginine vasopressin release. To further clarify the effects of ALP on the HPA axis in humans, in six normal young women (26-34 yr old) we studied the(More)
PURPOSE The aim of this study was to evaluate the reliability of intraoperative laser-Doppler measurements in predicting the occurrence of anastomotic leak in patients with colorectal cancer undergoing stapled straight anastomosis to the rectum. METHODS A prospective study was undertaken on 55 patients with rectal cancer or distal sigmoid cancer(More)
HYPOTHESIS Perioperative administration of a supplemented enteral formula may reduce the rate of postoperative infections. DESIGN Prospective, randomized, double-blind clinical trial. SETTING Department of surgery at a university hospital. PATIENTS Two hundred six patients with neoplasm of colorectum, stomach, or pancreas. INTERVENTION Patients were(More)