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Research suggests that duration of deafness prior to cochlear implantation affects postoperative speech recognition in adults. Duration of deafness usually is defined as the number of years between the onset of profound deafness and implantation. The purpose of this study was to examine the effects of duration of deafness--expressed as percentage of life(More)
HYPOTHESIS The primary purpose of this study was to determine if children, > or =5 years old, with onset of deafness before the acquisition of spoken language (i.e., prelingually deafened) derived more benefit from multichannel cochlear implants than from conventional hearing aids. It was hypothesized that children who used oral communication (speech plus(More)
Preoperative and postoperative efficacy results are reported for the first 58 children with 18 months of implant experience in the United States. A within-subjects repeated-measures design was used to compare preoperative performance with hearing aids to postoperative performance with the CLARION Multi-Strategy Cochlear Implant. The results revealed(More)
OBJECTIVE To assess the auditory skills in everyday situations of prelingually deafened children with Clarion cochlear implants compared with hearing aids used preoperatively. STUDY DESIGN The Meaningful Auditory Integration Scale (MAIS) was used to determine the preoperative and postoperative auditory skills of the children. RESULTS AND DISCUSSION(More)
The complete response (CR) rate of disseminated germ-cell tumors with current aggressive chemotherapy and surgical resection of localized residual disease is between 70%-80%. Most patients who relapse do so within the first year of therapy. We have observed seven patients with germ-cell tumors treated with a variety of modalities who relapsed after more(More)
This study was designed to determine the maximum tolerated dose (MTD) of high-dose melphalan (HDM), with peripheral blood stem cell support, that could be given twice within 90 days to patients with multiple myeloma. Twenty patients received tandem HDM at 160, 180 or 200 mg/m2 and a total of 55 were treated at the estimated MTD of 200 mg/m2. Seventeen of 55(More)
OBJECTIVE To evaluate the speech performance of children with the Clarion Multi-Strategy Cochlear Implant. PATIENTS Prelingually deafened children who had received the Clarion implant. METHODS The Spondee and Monosyllable Word Identification subtest of the Early Speech Perception test, the Glendonald Auditory Screening Procedure (GASP), and the(More)
BACKGROUND There is great interpatient variability in the number of peripheral blood stem cells collected, as measured by CD34+ cell content, after the administration of chemotherapy and a growth factor. The ability to predict patients who fail to yield adequate quantities of CD34+ cells would be of value. However, very few reports include large numbers of(More)