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In an elderly pool of 3288 subjects (65-84 years of age), taking part in the Italian Longitudinal Studies on Aging (ILSA). We evaluated the prevalence of acute myocardial infarction (AMI), the stroke, the non-fatal AMI+stroke cases in relation to the larger or smaller values of the apolipoprotein-B (Apo-B) level considered as cutoff point of normality (150(More)
The term "successful aging" appeared in the first issue of "The Gerontologist" in 1961. During the successive years, this expression has changed its meaning. Nowadays, successful aging means "absence of diseases and disabilities, maintenance of high levels of physical and cognitive abilities, preservation of the social and productive activities". It has(More)
IFN-alpha represents the treatment of choice in chronic hepatitis C. It acts directly on the cells infected by the virus and indirectly via the cytokine network. We studied the behavior of interleukin 6 (IL-6), a cytokine that is particularly active in the liver and considered an index of liver inflammation and necrosis, in order to evaluate the(More)
It is assumed that the increased incidence of neoplastic pathologies with advancing age is correlated with the immunosenescence and with the altered immune-surveillance. The present study was aimed at evaluating the role of the immunocompetent system and immunosenescence in carcinogenesis. A pool of 99 subjects (38 females, 61 males) has been analyzed in(More)
IFN alpha treatment is able to produce dose-related side effects, such as depression, in the central nervous system. We assessed the effects on depression of four different types of IFN alpha (recombinant IFN alpha 2a, recombinant IFN alpha 2b, lymphoblastoid IFN alpha, leukocyte IFN alpha), administered at the same doses in four homogeneous groups of(More)
The longevity is a complex phenomenon in which specific genetic properties seem to play a role. The present study intended to reconstruct the genealogical tree of 12 subjects, being residents of one Northern and one Southern province of Italy, in order to establish the longevity of the ancestors. Detailed studies have been performed in the registry offices(More)
The increased longevity brings to the appearance of more polypathologies, being frequently of chronic-degenerative type, and also an increased use of pharmaca. The present study evaluated the usual drug consumption in the ultralongevous people in comparison with their clinical conditions. A total of 602 centenarians were involved: clinical anamnesis,(More)
The increase in life expectancy, the decrease of birth rate, and of the death rate in advanced ages caused, particularly in the industrialized countries, a progressive demographic transformation of the society, characterized by an increased proportion of the elderly. We assist an inevitable increase of morbidity and disability, not only due to the global(More)
This study aimed at verifying the International Diabetes Federation (IDF)-indicated criteria in the elderly, characterized by a decrease of several normal values, the neglected evaluation of those values with aging, and an eventual decision of an obligatory consideration of the visceral obesity as a sign of the metabolic syndrome (MS), the relative(More)
In order to evaluate the significance of HbA1c in the diagnosis of Diabetes Mellitus (DM) and the risk of future DM in the elderly, the HbA1c and the fasting glycemia of 2167 elderly subjects of 65-84 years were determined, taking part in the epidemiological Italian Longitudinal Study on Aging (ILSA). The subjects were divided in 3 groups according to their(More)