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Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells
TLDR
It is shown that adaptation in mammalian cochlear hair cells is, as in other vertebrates, driven by Ca2+ entry, demonstrating the importance of this process as a fundamental mechanism in vertebrate hair cells. Expand
Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel
TLDR
It is found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to the Ca2+ chelator BAPTA can still respond to mechanical stimuli, and the presence of a large population of MET channels with pore properties that are distinct from those of normal MET channels is suggested. Expand
Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells
TLDR
This work shows that a mutant mouse model for progressive hearing loss in humans (DFNA36), which harbors a point mutation in the Tmc1 gene, shows that this mutation affects the MET channel pore, reducing its Ca2+ permeability and its affinity for the permeant blocker dihydrostreptomycin. Expand
GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord☆
TLDR
Extensive dye-coupling occurs between mammalian spinal cord ependymal cells and GABA effects were mediated by GABAA receptors but not GABA uptake transporters. Expand
Cholinergic Enhancement of Cell Proliferation in the Postnatal Neurogenic Niche of the Mammalian Spinal Cord
TLDR
It is shown that acetylcholine promotes the proliferation of ependymal cells in mice under both in vitro and in vivo conditions, highlighting the need for further investigation into how neurotransmitters regulate the response of the spinal cord to injury or during aging. Expand
Kv3.3 immunoreactivity in the vestibular nuclear complex of the rat with focus on the medial vestibular nucleus: Targeting of Kv3.3 neurones by terminals positive for vesicular glutamate transporter 1
TLDR
Evidence supporting a role for Kv3.3 subunits in vestibular processing by regulating neuronal excitability pre- and post-synaptically is provided. Expand
Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
TLDR
The results suggest that Piezo1 is unlikely to be a component of the MET channel complex in mammalian cochlear OHCs. Expand
Characterisation of cells in the postnatal neurogenic niche of the murine spinal cord
TLDR
GABA and ACh modulate neurogenesis and plasticity in other neurogenic niches and these results demonstrate that they are also capable of modulating cells within the neurogenic niche of the postnatal spinal cord. Expand
From the editors
In 2013, the SRA Council approved a new Specialty Group on Foundational Issues in Risk Analysis. The first part of this issue presents a series of six papers on foundational topics in risk analysis;Expand
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