Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells
- Laura F. Corns, Stuart L. Johnson, C. Kros, W. Marcotti
- BiologyJournal of Neuroscience
- 13 January 2016
This work shows that a mutant mouse model for progressive hearing loss in humans (DFNA36), which harbors a point mutation in the Tmc1 gene, shows that this mutation affects the MET channel pore, reducing its Ca2+ permeability and its affinity for the permeant blocker dihydrostreptomycin.
Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells
- Laura F. Corns, Stuart L. Johnson, C. Kros, W. Marcotti
- BiologyProceedings of the National Academy of Sciences
- 16 September 2014
It is shown that adaptation in mammalian cochlear hair cells is, as in other vertebrates, driven by Ca2+ entry, demonstrating the importance of this process as a fundamental mechanism in vertebrate hair cells.
Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel
- W. Marcotti, Laura F. Corns, Terri Desmonds, Nerissa K. Kirkwood, G. Richardson, C. Kros
- Biology, PhysicsJournal of Neuroscience
- 16 April 2014
It is found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to the Ca2+ chelator BAPTA can still respond to mechanical stimuli, and the presence of a large population of MET channels with pore properties that are distinct from those of normal MET channels is suggested.
GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord☆
- Laura F. Corns, J. Deuchars, S. Deuchars
- BiologyNeuroscience Letters
- 11 October 2013
Tmc 1 point mutation affects Ca 2 + sensitivity and block by dihydrostreptomycin of the mechanoelectrical transducer current of mouse outer hair cells
- Laura F. Corns, Stuart L. Johnson, C. Kros, W. Marcotti
- Biology
- 2019
Cholinergic Enhancement of Cell Proliferation in the Postnatal Neurogenic Niche of the Mammalian Spinal Cord
- Laura F. Corns, L. Atkinson, S. Deuchars
- BiologyStem Cells
- 26 June 2015
It is shown that acetylcholine promotes the proliferation of ependymal cells in mice under both in vitro and in vivo conditions, highlighting the need for further investigation into how neurotransmitters regulate the response of the spinal cord to injury or during aging.
Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs
- S. Boddy, Ricardo Romero-Guevara, M. Rivolta
- BiologyStem Cells International
- 1 March 2020
It is concluded that human-induced pluripotent cell lines that have been reprogrammed using nonintegrating mRNAs are capable to differentiate into otic cell types.
Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
- Laura F. Corns, W. Marcotti
- BiologyPhysiological Reports
- 1 February 2016
The results suggest that Piezo1 is unlikely to be a component of the MET channel complex in mammalian cochlear OHCs.
From the editors
- Kirsty Minton, Yvonne Bordon, A. Bocquet
- HistoryNature reviews. Immunology
- 2011
historians to plan a " symposium on the History of Technology with papers and sessions that would treat both the history of OMI and broader issues of science, technology,and education from the…
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