Laura F. Wetherill

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UNLABELLED Current interferon-based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct-acting antivirals (DAA) with the first protease-targeted drugs licensed in 2012. Many compounds are in the pipeline yet primarily target only three viral proteins, namely, NS3/4A protease, NS5B polymerase, and(More)
The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs). Detection of virus triggers signalling cascades that induce transcription of type I interferons including IFNbeta, which are(More)
Human natural killer (NK) cells play an important role in anti-viral immunity. However, studying their activation kinetics during infection is highly problematic. A clinical trial of a therapeutic virus provided an opportunity to study human NK cell activation in vivo in a controlled manner. Ten colorectal cancer patients with liver metastases received(More)
9 Laura F. Wetherill, Kristopher K. Holmes , Mark Verow , Marietta Müller, Gareth Howell, Mark 10 Harris, Colin Fishwick, Nicola Stonehouse, Richard Foster, G. Eric Blair, Stephen Griffin and 11 Andrew Macdonald 12 13 14 School of Chemistry, University of Leeds, UK 15 Leeds Institute of Molecular Medicine, Faculty of Medicine and Health, St James’s(More)
High-risk human papillomavirus type 16 (HPV16) is the primary causative agent of cervical cancer and therefore is responsible for significant morbidity and mortality worldwide. Cellular transformation is mediated directly by the expression of viral oncogenes, the least characterized of which, E5, subverts cellular proliferation and immune recognition(More)
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