Laura E. Kelly

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BACKGROUND With an ageing population and increasing demands on health and social care services, there is growing importance attached to the management of long-term conditions, including maximizing the cost-effectiveness of treatments. In line with this, there is increasing emphasis on the need to keep people both active and participating in daily life.(More)
Social networks are believed to affect health-related behaviors and health. Data to examine the links between social relationships and health in low- and middle-income country settings are limited. We provide guidance for introducing an instrument to collect social network data as part of epidemiological surveys, drawing on experience in urban India. We(More)
BACKGROUND The 39-item Parkinson's Disease Questionnaire (PDQ-39) is the most thoroughly validated and extensively used self-report measure for the assessment of health-related quality of life in people with Parkinson's (PwP). Given the extent of its use and increasing emphasis on electronic data capture, an e-based version of the PDQ-39, the ePDQ, has(More)
OBJECTIVE The internet is a valuable resource for accessing health information and support. We are developing an instrument to assess the effects of websites with experiential and factual health information. This study aimed to inform an item pool for the proposed questionnaire. METHODS Items were informed through a review of relevant literature and(More)
Human Cytomegalovirus (HCMV) affects 50 to 80% of the global population and establishes lifelong infections. Besides causing morbidity and mortality in immuno-compromised patients, HCMV is also a leading cause of congenital infections. The virus has evolved diverse mechanisms to modify the cellular environment to be beneficial to its replication as well as(More)
PURPOSE The Oxford Participation and Activities Questionnaire is a patient-reported outcome measure in development that is grounded on the World Health Organization International Classification of Functioning, Disability, and Health (ICF). The study reported here aimed to inform and generate an item pool for the new measure, which is specifically designed(More)
PURPOSE To identify the main issues of importance when living with long-term conditions to refine a conceptual framework for informing the item development of a patient-reported outcome measure for long-term conditions. MATERIALS AND METHODS Semi-structured qualitative interviews (n=48) were conducted with people living with at least one long-term(More)
Host allelic variation controls the response to B. anthracis and the disease course of anthrax. Mouse strains with macrophages that are responsive to anthrax lethal toxin (LT) show resistance to infection while mouse strains with LT non-responsive macrophages succumb more readily. B6.CAST.11M mice have a region of chromosome 11 from the CAST/Ei strain (a LT(More)
Health, health-related and health-care evaluation research can consider technologies that are adaptive in some way: this conference fo-cuses interest on Patient Reported Outcome Measures but arguably its remit could be widened. Why? Statistical methodology, health economics and health psychometrics are seen to converge in use of models and understanding of(More)
(6 week course) CREDITS: Three or Six V482/V582 course PROGRAM OVERVIEW The purpose of this three or six-­‐credit offering is to examine how hazards are managed through a mixture of lectures, case studies, and classroom discussions. The program is offered in an educational context that invites comparison of how the United States and Europe cope with known(More)