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Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form.(More)
Many features used in the analysis of pathology imagery are inspired by grading features defined by clinical pathologists as important for diagnosis and characterization. A large majority of these features are features of cell nuclei; as such, there is often the desire to segment the imagery into individual nuclei prior to feature extraction and further(More)
In this paper, we propose a low bit-rate speech codec based on vector quantization (VQ) of the mel-frequency cepstral coefficients (MFCCs). We begin by showing that if a high-resolution mel-frequency cepstrum (MFC) is computed, good-quality speech reconstruction is possible from the MFCCs despite the lack of phase information. By evaluating the contribution(More)
Therapeutic targeting of the beta-adrenergic receptors has recently shown remarkable efficacy in the treatment of benign vascular tumors such as infantile hemangiomas. As infantile hemangiomas are reported to express high levels of beta adrenergic receptors, we examined the expression of these receptors on more aggressive vascular tumors such as(More)
We present an analysis of the utility of multispectral versus standard RGB imagery for routine H&E stained histopathology images, in particular for pixel-level classification of nuclei. Our multispectral imagery has 29 spectral bands, spaced 10 nm within the visual range of 420–700 nm. It has been hypothesized that the additional spectral bands contain(More)
Our paper will present an analysis of the utility of multispec-tral imagery versus standard RGB imagery for routine H&E-stained histopathology imagery, in particular for the classification of histologic classes, with a focus on nuclei detection. Our multispectral data consists of 29 spectral bands, spaced 10 nm within the visual range of 420-700 nm. It is(More)
Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5-10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2 to 20 cm. These lesions subsequently stabilize, undergo a spontaneous slow involution and are fully(More)
1. ABSTRACT The utility of nuclear features for automated cancer diagnosis has been well established. Use of cytoplasm and stroma features, however, has not been addressed in an computer-aided diagnosis system, although there has been speculation about the possible use of such features. For example, stroma in pancreatic cancer has been noted as displaying(More)
—The use of Mel-frequency cepstral coefficients (MFCCs) is well established in the fields of speech processing, particularly for speaker modeling within a Gaussian mixture model (GMM) speaker recognition system. The use of GMMs for speech enhancement applications has only recently been proposed in the literature; the concept of direct inversion of the(More)