Laura Deming

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PURPOSE This study is aimed to identify genes within the KRAS genomic amplicon that are both coupregulated and essential for cell proliferation when KRAS is amplified in lung cancer. EXPERIMENTAL DESIGN We used an integrated genomic approach to identify genes that are coamplified with KRAS in lung adenocarcinomas and subsequently preformed an RNA(More)
Static standing balance was compared in 10 subjects with hemiparesis resulting from a cerebrovascular accident (33-71 years of age), 10 young normal subjects (22-40 years of age), and 10 older normal subjects (48-78 years of age) using a quantitative maximal load test and a clinical evaluation. The maximal load test required subjects to maintain a standing(More)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologic perturbations. To test this hypothesis, a class of first(More)
NASA's EPOXI mission observed the disc-integrated Earth and Moon to test techniques for reconnoitering extrasolar terrestrial planets, using the Deep Impact flyby spacecraft to observe Earth at the beginning and end of Northern Hemisphere spring, 2008, from a range of ∼1/6 to 1/3 AU. These observations furnish high-precision and high-cadence empirical(More)
28 29 Ubiquitination is an essential post-translational regulatory process that can control protein stability, 30 localization, and activity. Ubiquitin is essential for eukaryotic life and is highly conserved, varying in 31 only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies 32 in S. cerevisiae indicate that(More)
Each human genome is a 3 billion base pair set of encoding instructions. Decoding the genome using deep learning fundamentally differs from most tasks, as we do not know the full structure of the data and therefore cannot design architectures to suit it. As such, architectures that fit the structure of genomics should be learned not prescribed. Here, we(More)
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