Laura Deming

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Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologic perturbations. To test this hypothesis, a class of first(More)
NASA's EPOXI mission observed the disc-integrated Earth and Moon to test techniques for reconnoitering extrasolar terrestrial planets, using the Deep Impact flyby spacecraft to observe Earth at the beginning and end of Northern Hemisphere spring, 2008, from a range of ∼1/6 to 1/3 AU. These observations furnish high-precision and high-cadence empirical(More)
Each human genome is a 3 billion base pair set of encoding instructions. Decoding the genome using deep learning fundamentally differs from most tasks, as we do not know the full structure of the data and therefore cannot design architectures to suit it. As such, architectures that fit the structure of genomics should be learned not prescribed. Here, we(More)
28 29 Ubiquitination is an essential post-translational regulatory process that can control protein stability, 30 localization, and activity. Ubiquitin is essential for eukaryotic life and is highly conserved, varying in 31 only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies 32 in S. cerevisiae indicate that(More)
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