Laura De Miguel

Learn More
Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE) have multiple defects in lymphocyte signaling and function that contribute to disease pathogenesis. Such defects could be attributed to alterations in metabolic processes, including abnormal control of lipid biosynthesis pathways. Here, we reveal that CD4+ T cells from SLE(More)
Membrane lipid microdomains (lipid rafts) play an important role in T cell function by forming areas of high lipid order that facilitate activation. However, their role in regulating T cell differentiation and function remains controversial. In this study, by applying a new approach involving microscopy and flow cytometry, we characterize membrane lipid(More)
In this work, we introduce a new class of functions defined on the interval-valued setting. These functions extend classical OWA operators but allow for different weighting vectors to handle the lower bounds and the upper bounds of the considered intervals. As a consequence, the resulting functions need not be an interval-valued aggregation function, so we(More)