Laura Cervino

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BACKGROUND AND PURPOSE Brain radiotherapy is limited in part by damage to white matter, contributing to neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) to model the dose-dependency and time course of radiation effects on white matter. MATERIALS AND METHODS Fifteen patients with high-grade(More)
Deformable image registration (DIR) of fractional high-dose-rate (HDR) CT images is challenging due to the presence of applicators in the brachytherapy image. Point-to-point correspondence fails because of the undesired deformation vector fields (DVF) propagated from the applicator region (AR) to the surrounding tissues, which can potentially introduce(More)
With the aim of maximally reducing imaging dose while meeting requirements for adaptive radiation therapy (ART), we propose in this paper a new cone beam CT (CBCT) acquisition and reconstruction method that delivers images with a low noise level inside a region of interest (ROI) and a relatively high noise level outside the ROI. The acquired projection(More)
Accurate lung tumor targeting in real time plays a fundamental role in image-guide radiotherapy of lung cancers. Precise tumor targeting is required for both respiratory gating and tracking. Gating is considered as the current state of the art for precise lung cancer radiotherapy, which irradiates the tumor when it moves into a predefined gating window.(More)
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