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Many human Y-chromosomal deletions are thought to severely impair reproductive fitness, which precludes their transmission to the next generation and thus ensures their rarity in the population. Here we report a 1.6-Mb deletion that persists over generations and is sufficiently common to be considered a polymorphism. We hypothesized that this deletion might(More)
Alfred the robot won first place in the Hors d'Oeuvres Anyone? event and also received an award for the best integrated effort at the 1999 American Association of Artificial Intelligence robot competition. The three unique features that Alfred displayed were: the ability to nudge his way through a crowd to cover a large serving area, a strong(More)
The Nursebot project is a multidisciplinary , multi-university effort aimed at developing mobile robotic assistants for the elderly. In this paper, we describe one such robot, Pearl. Pearl has two primary functions: (i) reminding people about routine activities such as eating, drinking, taking medicine, and using the bathroom, and (ii) guiding them through(More)
OBJECTIVE Autosomal dominant parkinsonism, hypoventilation, depression and severe weight loss (Perry syndrome) is an early-onset rapidly progressive disease. At autopsy, previous studies have found severe neuronal loss in the substantia nigra without Lewy bodies. Transactive response DNA-binding protein of 43 kDa (TDP-43) has recently been identified as a(More)
The mechanisms that underlie the selection of an inhibitory GABAergic axon's postsynaptic targets and the formation of the first contacts are currently unknown. To determine whether expression of GABAA receptors (GABAA Rs) themselves--the essential functional postsynaptic components of GABAergic synapses--can be sufficient to initiate formation of synaptic(More)
OBJECTIVE The most frequent known genetic causes of severe oligospermia (< 5 million sperm/ml) or azoospermia in men are Klinefelter's syndrome (KS), and deletions in the Y chromosome long arm (Yq). We aimed to compare the function of the pituitary-testicular axis in patients with severe oligospermia or azoospermia, idiopathic or associated with Y(More)