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Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy(More)
The Development of Screening Guidelines and Clinical Criteria of Predementia Alzheimer’s Disease (DESCRIPA) multicenter study enrolled patients with MCI or subjective cognitive complaints (SUBJ), a part of whom underwent optional brain perfusion SPECT. These patients were classified as SUBJ (n = 23), nonamnestic MCI (naMCI; n = 17) and amnestic MCI (aMCI; n(More)
abstraCt Aim To investigate the degree of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) on MRI, in clinical subtypes of MCI. Methods Consecutive non­demented subjects older than 55 years (n = 329) with an aver­ age age of 69 ± 8 years (mean ± SD) and MMSE score of 28 ± 2 were recruited from memory clinics of multiple centres.(More)
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