Laura A Jacox

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Craniofacial birth defects occur in 1 out of every 700 live births,(More)
The mouth arises from the extreme anterior domain (EAD), a region where the ectoderm and endoderm are directly juxtaposed. Here, we identify a "pre-mouth array" in Xenopus that forms soon after the cranial neural crest has migrated to lie on either side of the EAD. Initially, EAD ectoderm comprises a wide and short epithelial mass that becomes narrow and(More)
Graphical Abstract Highlights d A Xenopus pre-mouth cell array splits down the midline to surround the oral opening d The pre-mouth array forms by convergent extension of EAD ectoderm d EAD morphogenesis is directed by adjacent cranial neural crest d Wnt/PCP signaling is necessary and sufficient to elicit EAD convergent extension In Brief Jacox et al.(More)
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