Laurène Gressin

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Turnover of actin networks in cells requires the fast disassembly of aging actin structures. While ADF/cofilin and Aip1 have been identified as central players, how their activities are modulated by the architecture of the networks remains unknown. Using our ability to reconstitute a diverse array of cellular actin organizations, we found that ADF/cofilin(More)
Graphical Abstract Highlights d Stress-fiber-associated tropomyosin isoforms segregate to different actin filaments d Tropomyosin isoforms bind F-actin with different dynamics d Dynamic tropomyosin isoforms activate non-muscle myosin II d Stable tropomyosin isoforms protect actin filaments from ADF/cofilin In Brief Gateva et al. report that distinct(More)
Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and(More)
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