Laughlin Dawes

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Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a by-product of that process is unknown. Pheochromocytoma (PC12) and fibroblast (NIH 3T3) cell lines were transfected with portions of the gene for the human amyloid precursor(More)
This project examined risk factors (lifestyle, socio-economic and cultural) for Type 2 diabetes among 890 women in rural Jamaica in comparison to national and international trends via the Behavioural Risk Factor Surveillance System (BRFSS) and further analysis via the Kruskal Wallis and Mann-Whitney U tests. Nonparametric tests explored the relationship of(More)
Patients with advanced cancer and diabetes mellitus present a challenge to healthcare professionals. To establish how diabetes is currently being managed in these patients, we audited the care of patients who died in Cheltenham General Hospital over the previous 12 months with diagnoses of both diabetes mellitus and cancer. Management and monitoring of the(More)
We present the first quantitative analysis of atypical teratoid rhabdoid tumors (ATRT) in adults, including two patients from our own institutions. These are of interest as one occurred during pregnancy and one is a long-term survivor. Our review of pathological findings of 50 reported cases of adult ATRT leads us to propose a solely ectodermal origin for(More)
The bone age of a child indicates the skeletal and biological maturity of an individual. The most commonly applied clinical methods for Bone Age Assessment (BAA) are based on the visual examination of ossification of individual bones in radiographs of the left hand and the wrist by comparing with standard hand atlas. This kind of method is highly subjective(More)
An alternate form of the Alzheimer amyloid protein precursor mRNA that encodes a protease inhibitor domain has recently been reported. Oligonucleotide probes that differentiate between the two mRNAs are used to describe the expression of each amyloid precursor transcript in the human brain. RNA blot analyses show that one of the mRNAs is expressed(More)
Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence increases with age. There is a paucity of data regarding incidental cerebral findings in twins. We examined brain MRI data acquired from community-dwelling older twins to determine the prevalence and concordance of incidental(More)
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