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Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading*
FEN1 cleaves 5′ flaps at their base to create a nicked product for ligation. FEN1 has been reported to enter the flap from the 5′-end and track to the base. Current binding analyses support a veryExpand
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Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro
Human telomeres consist of multiple tandem hexameric repeats, each containing a guanine triplet. Guanosine-rich clusters are highly susceptible to oxidative base damage, necessitating base excisionExpand
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Acetylation regulates DNA repair mechanisms in human cells
ABSTRACT The p300-mediated acetylation of enzymes involved in DNA repair and replication has been previously shown to stimulate or inhibit their activities in reconstituted systems. To explore theExpand
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Histone hyperacetylation in the coding region of chromatin undergoing transcription in SV40 minichromosomes is a dynamic process regulated directly by the presence of RNA polymerase II.
SV40 chromosomes undergoing transcription operationally defined by the presence of RNA polymerase II (RNAPII) were immune-selected with antibody to RNAPII and subjected to secondary chromatinExpand
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HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates.
The process of base excision repair (BER) recognizes and repairs small lesions or inappropriate bases on DNA through either a short-patch or long-patch pathway. The enzymes involved in BER have beenExpand
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Programmed remodeling of hyperacetylated histone H4 and H3 organization on the SV40 genome during lytic infection.
The presence of nucleosomes containing hyperacetylated histone H4 and H3 on the early, late, and promoter regions of the SV40 genome in chromosomes isolated 30 min, 8 h, and 48 h post-infection wasExpand
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Reorganization of RNA polymerase II on the SV40 genome occurs coordinately with the early to late transcriptional switch.
The pattern of organization of RNA polymerase II (RNAPII) in wild-type and mutant cs1085 SV40 chromosomes isolated between 30 min and 48 h post-infection was determined using a combination ofExpand
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Epigenetic Regulation of Viral Biological Processes
It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of theExpand
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Virion-mediated transfer of SV40 epigenetic information
In eukaryotes, epigenetic information can be encoded in parental cells through modification of histones and subsequently passed on to daughter cells in a process known as transgenerational epigeneticExpand
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Valganciclovir Inhibits Human Adenovirus Replication and Pathology in Permissive Immunosuppressed Female and Male Syrian Hamsters
Adenovirus infections of immunocompromised pediatric hematopoietic stem cell transplant patients can develop into serious and often deadly multi-organ disease. There are no drugs approved forExpand
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