Larysa L Macewicz

Learn More
Cell adhesion, mediated by N-cadherin, is critical for embryogenesis since N-cadherin-null embryos die during mid-gestation with multiple developmental defects. To investigate the role of N-cadherin in heart muscle development, N-cadherin was specifically deleted from myocardial cells in mice. The structural integrity of the myocardial cell wall was(More)
The biological activity of Sambucus nigra bark lectin on Chinese hamster cells in vitro was investigated by comet-assay and cytotoxicity testing. Mitogenic properties at the concentrations 0.063-0.25 microg/ml (but not higher) were found, and the induction of DNA breaks at concentrations 0.5 microg/ml and higher is demonstrated. S. nigra bark lectin at(More)
A study of the glutathione status as a prerequisite of the detoxifying activity of the fetoplacental barrier was undertaken in different regions of the Ukraine that have been judged either 'clean', chemically polluted or radioactively contaminated with different summary effective equivalent annual expositional doses (SEEAED). In the samples from clean(More)
Using conditional-knockout animals, we studied the expression of the genes involved in the canonical Wnt signaling pathway (TCF-4, Axin-2) and the genes controlled by this signaling pathway (c-fos, cyclin D1, c-myc, and Cx43) in the myocardium of mice under the condition of embryonic cardio-specific ablation of one allele of the β-catenin gene. The(More)
The influence of cytokines LIF, SCF, IL-3, and EMAP II and the Laferobion (IFN-a2b) drug on the MGMT gene expression in human cell cultures has been studied. It was shown that exogenous cytokines can modulate the MGMT gene expression at the protein level. EMAP II is able to increase or decrease the MGMT level, depending on the experimental conditions.(More)
  • 1