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4-Aminoethylamino-emodin – a novel potent inhibitor of GSK-3β– acts as an insulin-sensitizer avoiding downstream effects of activated β-catenin
- R. Gebhardt, Katja S Lerche, +8 authors F. Gaunitz
- Biology, Medicine
- Journal of cellular and molecular medicine
- 18 January 2009
Glycogen synthase kinase‐3β (GSK‐3β) is a key target and effector of downstream insulin signalling. Using comparative protein kinase assays and molecular docking studies we characterize the… Expand
Synthesis and biological evaluation of new derivatives of emodin.
- Lars Teich, K. S. Daub, Vera Krügel, Ludwig Nissler, R. Gebhardt, K. Eger
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 November 2004
Drugs containing an anthraquinone moiety such as daunorubicin (Daunoblastin) and mitoxantrone (Onkotrone) constitute some of the most powerful cytostatics. They suppress tumor growth mainly by… Expand
Synthesis of 3‐Aryloxy‐2‐iodoemodines by Oxidation of Emodin with (Diacetoxyiodo)arenes
Hypervalent iodine oxidation of emodin (1) with various (diacetoxyiodo)arenes 2a−f in potassium hydroxide/methanol leading to 3-aryloxy-1,8-dihydroxy-2-iodo-anthraquinones 4a−f is reported.… Expand
Synthesis of Pyranoid Sugar α-Amino Acid Derivatives from 2-Oxo-Dgluconic Acid