Lars Schmitt

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A method was developed to quantify prostate metabolite concentrations using (1)H high-resolution magic angle spinning (HR-MAS) spectroscopy. T(1) and T(2) relaxation times (in milliseconds) were determined for the major prostate metabolites and an internal TSP standard, and used to optimize the acquisition and repetition times (TRs) at 11.7 T. At 1 degrees(More)
Adenovirus-based gene therapy may provide an alternative mode of treatment for prostate cancer, especially for late-stage and androgen-independent disease for which there is currently no effective treatment. Efficient adenovirus infection of target cells depends upon the presence of the coxsackie adenovirus cell surface receptor, CAR, which is the primary(More)
Proton high-resolution magic angle spinning ((1)H HR-MAS) NMR spectroscopy and quantitative histopathology were performed on the same 54 MRI/3D-MRSI-targeted postsurgical prostate tissue samples. Presurgical MRI/3D-MRSI targeted healthy and malignant prostate tissues with an accuracy of 81%. Even in the presence of substantial tissue heterogeneity, distinct(More)
The Continua Health Alliance is nearing the first release of its Design Guidelines, an important milestone towards the establishment of a personal telehealth ecosystem. These guidelines address the technical barrier for a personal telehealth ecosystem: interoperability amongst multivendor systems. This paper describes why it is essential to address(More)
The Continua Health Alliance, which was started in 2006 to enable an interoperable personal telehealth ecosystem, has become a major force in the personal telehealth domain. Within one year after the release of the Version One Design Guidelines over a dozen interoperable products have been officially Continua Certified and many more are coming. In parallel(More)
In this paper we derive an enhanced power control algorithm, fitting into the up/down control scheme, as it is considered in the frequency division duplex (FDD) mode of the current 3GPP standard. Analysis of the classical up/down power control scheme unveils, that with increasing velocities the power control performance degrades, as the fixed step size(More)
PURPOSE To retrospectively investigate size criteria for the identification of chance-detected lesions at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging of prostate cancer. MATERIALS AND METHODS Approval of the committee on human research and written informed consent were obtained. This study was HIPAA compliant. Endorectal MR(More)
We have constructed a high-resolution genomic microarray of human chromosome 16q, and used it for comparative genomic hybridization analysis of 16 prostate tumors. We demarcated 10 regions of genomic loss between 16q23.1 and 16qter that occurred in five or more samples. Mining expression array data from four independent studies allowed us to identify 11(More)
PURPOSE To retrospectively determine the magnetic resonance (MR) and MR spectroscopic imaging features of high-grade prostatic intraepithelial neoplasia (HGPIN) in patients with prostate cancer. MATERIALS AND METHODS Approval of the committee on human research was obtained, with a waiver of consent for this HIPAA-compliant study. Endorectal MR imaging and(More)