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 In guinea-pig ventricular myocytes, cell swelling by incubation in hypotonic solution caused a pronounced shortening of the action potential duration (APD90: 15.5±14.6% compared to control; mean ± SD) after a latency of 12 min when the intracellular ATP concentration was 2 mM. This shortening was partially reversible within 10 min after reperfusion with(More)
1. Transmembrane current through ATP-regulated K(+) channels (IK(ATP)) was measured in ventricular heart cells of the guinea-pig in the whole-cell and cell-attached patch configurations under conditions of metabolic poisoning with the mitochondrial uncoupler 2,4-dinitrophenol (DNP). 2. Maintained exposure of the cells to DNP resulted in a transient(More)
A semiquantitative determination of the cutaneous blood flow is possible by a simple thermic method using a heat conduction probe. There is a quantitative uncertainty because of the possible existence of relatively big vessels which do not participate in the blood supply of the examined tissular region but in the determination of the convection within the(More)
All techniques for measuring thermal blood flow have in common a small heat source and two temperature difference sensors placed in or on the tissue. The measured temperature difference can be quasistationary, nonstationary or constant, depending upon the heating pattern. Its extent and course, respectively the heating output in the case of pulse(More)