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BACKGROUND National prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. Palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. OBJECTIVE To assess the registration of(More)
AIM To characterise changes in pancreatic beta cell mass during the development of diabetes in untreated male C57BLKS/J db/db mice. METHODS Blood samples were collected from a total of 72 untreated male db/db mice aged 5, 6, 8, 10, 12, 14, 18, 24 and 34 weeks, for measurement of terminal blood glucose, HbA1c, plasma insulin, and C-peptide. Pancreata were(More)
OBJECTIVE To investigate any association between selective serotonin reuptake inhibitors (SSRIs) taken during pregnancy and congenital major malformations. DESIGN Population based cohort study. PARTICIPANTS 493 113 children born in Denmark, 1996-2003. MAIN OUTCOME MEASURE Major malformations categorised according to Eurocat (European Surveillance of(More)
INTRODUCTION Laboratory and epidemiologic studies have suggested a modifying effect of cardiac glycosides (for example, digoxin and digitoxin) on cancer risk. We explored the association between digoxin treatment and invasive breast cancer incidence among postmenopausal Danish women. METHODS We used Danish registries to identify 5,565 postmenopausal women(More)
BACKGROUND Current data on incidence of interstitial lung diseases (ILDs) are sparse and concerns about an increasing trend have been raised. We examined incidence rates (IRs) of ILDs and changes in IRs between 1995 and 2005. METHODS All persons with a first-time hospital discharge or outpatient diagnosis of ILD were identified through the Danish National(More)
BACKGROUND AND AIM Maternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given the lack of specificity for both the exposures and the outcomes, other factors related to infection such as impaired maternal immune function may be involved in the causal pathway. If impaired maternal immune(More)
OBJECTIVE To determine whether use of antiepileptic drugs during pregnancy may increase the risk of spontaneous abortion or stillbirth. DESIGN Population based cohort study. SETTING Register based study in Denmark, 1997-2008. PARTICIPANTS 983,305 pregnancies identified in the Danish medical birth register and the Danish national hospital discharge(More)
BACKGROUND Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. METHODS Set in Northern Denmark, our population-based prevalence study included 216,042 women who had a live birth after the 20th(More)
Population-based prescription databases in Nordic countries have become a mainstay of epidemiologic research. Denmark has both national and regional population-based prescription databases. Aarhus University Prescription Database collects data on reimbursed medications dispensed at all community pharmacies of the North Denmark Region and the Central Denmark(More)