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Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report, for the first time, that the BMP pathway is a positive regulator of muscle mass. Increasing the expression of(More)
Thyroid hormone (TH) deficiency during development causes severe and permanent neuronal damage, but the primary insult at the tissue level has remained unsolved. We have defined locomotor deficiencies in mice caused by a mutant thyroid hormone receptor alpha1 (TR alpha1) with potent aporeceptor activity attributable to reduced affinity to TH. This allowed(More)
OBJECTIVES The aim of this study was to examine the influence of visual and motor processes on the deterministic and stochastic structure of force output and motor unit discharge variability. METHODS Young adult subjects produced continuous, isometric force at 3, 6, 12, and 24% of their maximal voluntary contraction at low and high visual gain levels(More)
—Current cloud computing infrastructure offerings are lacking in interoperability, which is a hindrance to the advancement and adoption of the cloud computing paradigm. As clouds are made interoperable, federations of clouds may be formed. Such federations are from the point of view of the user not burdened by vendor lock-in, and opens for business(More)
—Cloud infrastructure providers may form Cloud federations to cope with peaks in resource demand and to make large-scale service management simpler for service providers. To realize Cloud federations, a number of technical and managerial difficulties need to be solved. We present ongoing work addressing three related key management topics, namely,(More)
An archeological excavation is usually a rapidly evolving environment: several factors (weather, costs, permissions) force the work to be concentrated in a few weeks. Moreover, excavating is essentially a mono-directional operation, which constantly modifies the state of the site. Since most of the interpretation is performed in a second stage, it is(More)
Skeletal muscle wasting and impaired muscle function in response to mechanical ventilation and immobilization in intensive care unit (ICU) patients are clinically challenging partly due to 1) the poorly understood intricate cellular and molecular networks and 2) the unavailability of an animal model mimicking this condition. By employing a unique porcine(More)
Recent evidence suggests that ventricular ejection is partly powered by a delayed development of force, i.e., stretch activation, in regions of the ventricular wall due to stretch resulting from torsional twist of the ventricle around the apex-to-base axis. Given the potential importance of stretch activation in cardiac function, we characterized the(More)
INTRODUCTION Critically ill ICU patients commonly develop severe muscle wasting and impaired muscle function, leading to delayed recovery, with subsequent increased morbidity and financial costs, and decreased quality of life for survivors. Critical illness myopathy (CIM) is a frequently observed neuromuscular disorder in ICU patients. Sepsis, systemic(More)
BACKGROUND Acute quadriplegic myopathy (AQM) or critical illness myopathy (CIM) is frequently observed in intensive care unit (ICU) patients. To elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness associated with AQM, a gene expression profile was analyzed at time(More)