Lars-Henrik Meyer

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Patients with spasticity typically present with an increased muscle tone that is at least partly caused by an exaggerated stretch reflex. However, intrinsic changes in the skeletal muscles, such as altered mechanical properties of the extracellular matrix or the cytoskeleton, have been reported in response to spasticity and could contribute to hypertonia,(More)
Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the joints that can cause severe disability. While the role of inflammatory cells in the pathogenesis of RA has been well established, the specific contribution of resident cells within the synovial membrane, especially those of mesenchymal origin, has become the object of closer scrutiny only(More)
Mitogen-activated protein kinases (MAPKs) have been associated with the pathogenesis of rheumatoid arthritis (RA), but the individual contributions of the three MAPK family members are incompletely understood. Although previous data have established a role for c-Jun N-terminal kinase (JNK) and extracellular signal-related kinase (ERK) in different animal(More)
OBJECTIVE We analysed the role of the adaptor molecule four-and-a-half Lin11, Isl-1 & Mec-3 (LIM) domain protein 2 (FHL2) in the activation of fibroblast-like synoviocytes in human rheumatoid arthritis (RA) and tumour necrosis factor α (TNFα)-dependent animal models of the disease. METHODS Synovial tissues of patients with RA and osteoarthritis (OA) as(More)
Organotypische Hornhautäquivalente werden als In-vitro-Modelle für Arzneistoffabsorptionsuntersuchungen verwendet. Viele ophthalmologische Wirkstoffe werden zur Erhöhung der Bioverfügbarkeit als Ester-Prodrugs eingesetzt. Es wurde die Esteraseaktivität von drei kornealen humanen Zelllinien (Epithel-, Stroma- und Endothelzellen) sowie von exzidierter(More)
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