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The mammalian diaphanous-related formin (mDia1), a Rho-regulated cytoskeletal modulator, has been shown to promote T lymphocyte chemotaxis and interaction with antigen presenting cells, but the mechanisms underpinning mDia1 roles in these processes have not been defined. Here we show that mDia1(-/-) T cells exhibit impaired lymphocyte function-associated(More)
Personalized medicine is the ability to tailor healthcare decisions based on an individual's unique characteristics (genetics, demographic information, healthcare experience, environment and social factors) to more accurately diagnose the individual's disease, predict its outcomes, and select treatments that increase the chances of a successful outcome and(More)
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