Lars Börjesson

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BACKGROUND Colorectal cancer usually gives rise to a specific anti-tumor immune response, but for unknown reasons the resulting immunity is not able to clear the tumor. Recruitment of activated effector lymphocytes to the tumor is important for efficient anti-tumor responses, while the presence of regulatory T cells (Treg) down-modulate tumor-specific(More)
The non-adrenergic relaxation of carbachol precontracted longitudinal muscle of the rat distal colon was investigated. Intrinsic nerves were activated by the nicotinic, ganglionic receptor agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). DMPP at 1 and 4 microM caused a relaxation that was markedly antagonized by the nerve blocker tetrodotoxin (1(More)
In a systematic study we investigate the effect of dopant level and hydration on the short-range structure of the proton conducting perovskite-type oxide BaInxZr1−xO 3−x/2 (x = 0 − 0.75), using infrared and Raman spectroscopy. The results show that doping leads to significant local distortions of the average cubic structure of these materials. By increasing(More)
INTRODUCTION The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown. Galectins are carbohydrate-binding lectins involved in a large number of physiological and pathophysiological processes. Little is known about the role of galectins in human UC. In this immunohistochemical exploratory study, both epithelial and inflammatory cell(More)
We studied, by organ bath methodology, how experimental colitis in rat, induced by the administration of dextran sulphate sodium (DSS) in the drinking water (3% for 3 or 7 days, or 5% for 7 days; Controls received ordinary tap water), may influence spontaneous, contractile activity of the longitudinal muscle layer. DSS treatment caused a dose-dependent(More)
McN-A-343, which is a ligand at muscarinic receptors on myenteric ganglia, was found to concentration-dependently (1-44 microM) elicit non-adrenergic relaxation of the longitudinal muscle of rat distal colon, having been precontracted with carbachol (1 microM). This effect was partly antagonized by the muscarinic receptor antagonist, pirenzepine (0.3(More)
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