Larry Reiter

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A conceptual/computational framework for exposure reconstruction from biomarker data combined with auxiliary exposure-related data is presented, evaluated with example applications, and examined in the context of future needs and opportunities. This framework employs physiologically based toxicokinetic (PBTK) modeling in conjunction with numerical(More)
In two experiments, human subjects showed a reduced eyewink reflex to an airpuff (S2) if it was preceded by a light flash or a noise burst (S1). The first (N=6) showed that a light inhibited the blink maximally at a 100-msec lag. In the second (N=8), thresholds for noise pips were established with the method of limits. Then the pips were presented in(More)
This study was designed to determine the effectiveness of reflex modulation (RM) audiometry in assessing the hearing sensitivity of difficult-to-test subjects. RM describes the inhibitory effect of a tone upon a subsequently elicited eyeblink reflex. Five ENT subjects were referred to the University of Kansas audiology clinic because of medicolegal problems(More)
Eyeblink reflexes to airpuffs to the orbit are inhibited by preliminary tones even of low intensity, and the amount of inhibition or "reflex modulation" (RM) is correlated with tone loudness. Brief pure tones were presented 100 msec prior to an airpuff to the eye and eyeblink amplitude was recorded in 7 normal-hearing adults. Tones of several levels were(More)
  • L Reiter
  • 1978
The stated objectives of these Target Organ Toxicity Symposia are to review the morphology, physiology, and biochemistry of the particular organ system, describe means used to assess toxicity , evaluate tests used for this assessment, and finally, to propose the application of recent advances to the development of practical test procedures. Basically, the(More)
We present a case study in which the jaw/mouth-open procedure during air-conduction testing is employed to both detect and remediate external auditory meatal collapse. A prospective investigation was also conducted to compare the efficacy of the proposed jaw/mouth-open procedure with that of the traditional insert receivers in remediating meatal collapse(More)
  • L Reiter
  • 1978
Locomotor activity measurements have been used extensively to evaluate chemically-induced changes in CNS function. This paper focuses on several factors including apparatus, age, biological rhythm, and social setting, which influence both locomotor activity levels per se and chemically induced changes in these activity levels. These data illustrate that(More)
  • L A Reiter
  • 1981
Two experiments were conducted on normal hearing adults to assess the audiometric test potential of reflex modulation (RM) when administered according to the descending method of limits. RM describes the inhibitory effect of a tone upon a subsequently occurring eyeblink reflex. Although RM conducted according to the method of constant stimuli has already(More)
If a weak tone precedes an intense tone, then the acoustic startle eyeblink reflex elicited by the stronger stimulus is inhibited. It has been suggested that the leading stimulus gives rise to a protective middle ear reflex that attenuates the effective intensity of the second. This hypothesis was tested and disproved. In seven subjects intense tone bursts(More)
  • L A Reiter
  • 1981
The term reflex modulation (RM) as used here refers to an auditorially induced modification in the magnitude of a cutaneous reflex. the audiometric potential of RM was examined in two children, while they enjoyed viewing silent cartoons. Eyeblink reflexes elicited by an airpuff were reduced in amplitude or "inhibited" by a variety of audible tones presented(More)
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