Larry Nagahara

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This manuscript summarizes current thinking on the value and promise of evolving circulating tumor cell (CTC) technologies for cancer patient diagnosis, prognosis, and response to therapy, as well as accelerating oncologic drug development. Moving forward requires the application of the classic steps in biomarker development–analytical and clinical(More)
Stochastic on-off conductivity switching observed in phenylene-ethynylene oligomers has been explained in terms of changes in ring conformations, or electron localization, or both. We report the observation of stochastic on-off switching in the simplest of wired molecules: octanedithiol, decanedithiol, and dodecanedithiol bonded on an Au(111) surface.(More)
This paper presents a glucose sensor using conducting polymer/enzyme nanojunctions and demonstrates that unique features can arise when shrinking a sensor to the nanometer scale. Each nanojunction is formed by bridging a pair of nanoelectrodes separated with a small gap (20−60 nm) with polyaniline/glucose oxidase. The signal transduction mechanism of the(More)
Advanced technologies and biomaterials developed for tissue engineering and regenerative medicine present tractable biomimetic systems with potential applications for cancer research. Recently, the National Cancer Institute convened a Strategic Workshop to explore the use of tissue biomanufacturing for development of dynamic, physiologically relevant in(More)
We have studied electron transport properties of unsubstituted oligo(phenylene ethynylene) (OPE) (1) and nitro-substituted OPE (2) covalently bound to two gold electrodes. The conductance values of single 1 and 2 are approximately 13 and approximately 6 nS, respectively. In addition to a decrease in the conductance, the presence of the nitro moiety leads to(More)
Real-time detection of trace chemicals, such as explosives, in a complex environment containing various interferents has been a difficult challenge. We describe here a hybrid nanosensor based on the electrochemical reduction of TNT and the interaction of the reduction products with conducting polymer nanojunctions in an ionic liquid. The sensor(More)
  • Nicole M Moore, Larry A Nagahara
  • American journal of physiology. Cell physiology
  • 2014
One of the major challenges in cancer research today is developing new therapeutic strategies to control metastatic disease, the spread of cancer cells from a primary tumor to seed in a distant site. Advances in diagnosis and treatment options have increased the survival rate for most patients with local tumors; however, less progress has been made in(More)
The recent surge of interest in nanomaterials is driven by not only the need of ever-increasing miniaturization of microelectronics but also the discovery of many novel phenomena that occur on the nanoscale.1 Conducting polymers are attractive for a variety of applications.2 Bulk polymer materials are often described as highly conductive nanocrystalline(More)