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Temporally graded retrograde memory loss, with a disproportionate impairment of recent relative to remote memories, is considered a hallmark of medial temporal lobe amnesia. According to consolidation theory, the hippocampal complex, which includes the hippocampal formation, parahippocampal gyrus, the entorhinal and perirhinal cortex, plays a time-limited(More)
An effect size analysis of neurocognitive function in patients with major depressive disorder using meta-analytic principles was conducted. The results from 726 patients with depression and 795 healthy normal controls revealed that depression had the largest effect on measures of encoding and retrieval from episodic memory. Intermediate effect sizes were(More)
Two components of verbal fluency performance--clustering (i.e., generating words within subcategories) and switching (i.e., shifting between subcategories)--were examined in patients with dementia of the Alzheimer type (DAT), patients with dementia with Parkinson's disease (DPD), nondemented patients with Parkinson's disease (NPD), and demographically(More)
BACKGROUND We present information regarding the standardization, reliability and clinical validity of two versions of the Behavioural Neurology Assessment (BNA). The BNA-Long Form consists of 24 subtests within separate domains: Attention, Memory, Language, Visuospatial Function, Executive Function, and Praxis. The BNA-Short Form consists of 13 subtests(More)
Increased difficulty with response inhibition occurs with age, although there is some controversy as to whether increased interference on Stroop tasks reflects difficulties with response inhibition or simply reflects generalized cognitive slowing. The Victoria Stroop Test (VST) is a brief, easily administered, psychometrically sound version of Stroop's(More)
BACKGROUND Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency. OBJECTIVE To determine the ability of abbreviated fluency measures in the clinic setting (1-minute letter F and animal fluency tests) to(More)
A cerebral cortical cholinergic reduction in dominantly inherited olivopontocerebellar atrophy (OPCA) was recently described. Although the magnitude of the cholinergic reduction was similar to that observed in Alzheimer's disease (AD), none of the OPCA patients was reported to have been demented. We now describe a comprehensive neuropsychological assessment(More)
For over a hundred years, it has been accepted that remote memories are less vulnerable to disruption than are recent memories. The standard consolidation model posits that the hippocampus and related structures are temporary memory structures, necessary for acquisition, retention , and retrieval of all explicit (declarative) memories until they are(More)
Despite extensive investigations of the role of recollection and familiarity on laboratory-acquired memories, there is a dearth of such research on memories formed in real life settings. We used the Remember/Know paradigm to investigate the relative contribution of recollection and familiarity processes to memory of public historical events reported in the(More)
We describe a structured, theory-driven training programme for individuals with moderate-to-severe memory impairment in the use of emerging commercial technology. We demonstrate its application to 10 individuals with memory impairment from a variety of aetiologies. A within-subject, ABAB multi-case experimental design was used to evaluate the impact of(More)