Larry Goldstein

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The interobserver reliability of a rating scale employed in several multicenter stroke trials was investigated. Twenty patients who had a stroke were rated with this scale by four clinical stroke fellows. Each patient was independently evaluated by one pair of observers. The degree of interrater agreement for each item on the scale was determined by(More)
The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic treatments(More)
Let W be a random variable with mean zero and variance σ2. The distribution of a variate W , satisfying EWf(W ) = σ2Ef (W ) for smooth functions f , exists uniquely and defines the zero bias transformation on the distribution of W . The zero bias transformation shares many interesting properties with the well known size bias transformation for non-negative(More)
Stroke ranks as the third leading cause of death in the United States. It is now estimated that there are more than 700 000 incident strokes annually and 4.4 million stroke survivors.1,2 The economic burden of stroke was estimated by the American Heart Association to be $51 billion (direct and indirect costs) in 1999.3 Despite the advent of treatment of(More)
The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Background and Purpose—This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of a first stroke. Methods—Writing group members were(More)
Since their return from Persian Gulf War (PGW), many veterans have complained of symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty with concentration. The causes of the symptoms remain unknown. Because these veterans were exposed to a combination of chemicals including pyridostigmine bromide (PB), DEET, and(More)
BACKGROUND AND PURPOSE The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as used by non-neurologists in the context(More)
BACKGROUND AND PURPOSE This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk. METHODS Writing group members were nominated by the committee chair on the basis of each writer's previous work in relevant topic areas and were approved by the(More)
BACKGROUND AND PURPOSE The purpose of this study was to analyze recovery of motor function in a cohort of patients presenting with an acute occlusion in the carotid distribution. Analysis of recovery patterns is important for estimating patient care needs, establishing therapeutic plans, and estimating sample sizes for clinical intervention trials. (More)