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Convergence to the Poisson distribution, for the number of occurrences of dependent events, can often be established by computing only first and second moments, but not higher ones. This remarkable result is due to Chen (1975). The method also provides an upper bound on the total variation distance to the Poisson distribution, and succeeds in cases where(More)
Let W be a random variable with mean zero and variance σ 2. The distribution of a variate W * , satisfying EW f (W) = σ 2 Ef ′ (W *) for smooth functions f , exists uniquely and defines the zero bias transformation on the distribution of W. The zero bias transformation shares many interesting properties with the well known size bias transformation for(More)
Since their return from Persian Gulf War (PGW), many veterans have complained of symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty with concentration. The causes of the symptoms remain unknown. Because these veterans were exposed to a combination of chemicals including pyridostigmine bromide (PB), DEET, and(More)
Comprehensive data on the costs of multiple sclerosis is sparse. We conducted a survey of 606 persons with MS who were members of the National Multiple Sclerosis Society to obtain data on their cost of personal health services, other services, equipment, and earnings. Compensation of such cost in the form of health insurance, income support, and other(More)
Berry Esseen type bounds to the normal, based on zero-and size-bias couplings, are derived using Stein's method. The zero biasing bounds are illustrated with an application to combinatorial central limit theorems where the random permutation has either the uniform distribution or one which is constant over permutations with the same cycle type and having no(More)
Intracranial vasculitis, or primary angiitis of the central nervous system (PACNS), is an uncommon, often fatal disorder that frequently responds to aggressive immunosuppressive therapy. Magnetic resonance imaging (MRI), cerebral angiography, and brain biopsy are diagnostic modalities that vary in invasiveness and diagnostic accuracy. The purpose of this(More)
BACKGROUND AND PURPOSE The intention-to-treat analysis of data from the placebo-controlled Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial found 80 mg atorvastatin per day reduced the risk of stroke and major coronary events in patients with recent stroke or transient ischemic attack. This benefit was present despite only a(More)
BACKGROUND AND PURPOSE The purpose of this study was to analyze recovery of motor function in a cohort of patients presenting with an acute occlusion in the carotid distribution. Analysis of recovery patterns is important for estimating patient care needs, establishing therapeutic plans, and estimating sample sizes for clinical intervention trials. (More)
The interobserver reliability of a rating scale employed in several multicenter stroke trials was investigated. Twenty patients who had a stroke were rated with this scale by four clinical stroke fellows. Each patient was independently evaluated by one pair of observers. The degree of interrater agreement for each item on the scale was determined by(More)