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Therapy of leishmaniasis: superior efficacies of liposome-encapsulated drugs.
Liposomes containing antimonial compounds trapped in the aqueous phase were tested in the treatment of experimental leishmaniasis. The rationale of this approach was based on the hypothesis that theExpand
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Haemoflagellates: commercially available liquid media for rapid cultivation.
The successful cultivation of a variety of haemoflagellates in three different liquid media is reported. These media include medium 199, Grace's insect tissue-culture medium and Schneider'sExpand
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Visceral Leishmaniasis in the German Shepherd Dog. I. Infection, Clinical Disease, and Clinical Pathology
Two groups of three German shepherd dogs each were inoculated with Leishmania chagasi or Leishmania donovani amastigotes and the infection was followed for 82 days. The dogs developed a persistentExpand
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Inbred mice as model hosts for cutaneous leishmaniasis. I. Resistance and susceptibility to infection with Leishmania braziliensis, L. mexicana, and L. aethiopica.
The susceptibility of 12 strains of inbred mice representing a broad genetic spectrum to infection of Leishmania braziliensis, L. mexicana and L. aethiopica was determined. Levels of susceptibilityExpand
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Visceral Leishmaniasis in the German Shepherd Dog. II. Pathology
Three German shepherd dogs were inoculated with Leishmania chagasi and three with Leishmania donovani and the infection was followed for 82 days. All infected dogs developed splenomegaly andExpand
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Human cutaneous leishmaniasis caused by Leishmania donovani s.l. in Kenya.
Our laboratory is characterizing Leishmania stabilates and isolates from active leishmaniasis cases. Smears and cultures from aspirates made on different dates from a single lesion on the bridge ofExpand
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Leishmaniasis: military significance and new hope for treatment.
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Experimental infection of Mystromys albicaudatus with Leishmania braziliensis: pathology.
Thirty-four Mystromys albicaudatus were injected intradermally with Leishmania braziliensis promastigotes and examined and killed during a 12-week period. All animals developed single cutaneousExpand
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Liposomes in leishmaniasis: therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline.
Abstract This study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanialExpand
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Identification of Leishmania spp. by multiple isozyme analysis.
Biochemical data as enzyme profiles which were obtained by cellulose acetate electrophoresis (CAE) are reported on 44 Leishmania isolates. These enzyme profiles contain data from 25 enzyme systems.Expand
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