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OBJECTIVE To characterize serologic and clinical features and outcome of dogs with leptospirosis that were treated conservatively (i.e., medical management alone) or with hemodialysis. DESIGN Retrospective study. ANIMALS 36 dogs with leptospirosis. PROCEDURE History; results of physical examinations, ultrasonography, and serologic, hematologic, and(More)
The pathologic changes associated with hyperthyroidism (adenomatous hyperplasia, adenoma of the thyroid gland) have been well characterized in cats, but the pathogenesis of these changes remains unclear. In this research, we undertook a case-control study to search for potential risk factors for this disease. Owners of 379 hyperthyroid and 351 control cats(More)
BACKGROUND Acute kidney injury (AKI) is a common and often fatal disorder in dogs. HYPOTHESIS Urine neutrophil gelatinase-associated lipocalin (NGAL)/creatinine ratio is a sensitive and specific biomarker of AKI in dogs. ANIMALS Ninety-four dogs. METHODS Prospective study. Dogs were classified as follows: (1) healthy dogs, (2) dogs with lower urinary(More)
OBJECTIVE To test efficacy and safety of recombinant human erythropoietin (r-HuEPO) administration in dogs and cats with naturally developing chronic renal failure. DESIGN Case series. ANIMALS 6 client-owned dogs and 11 client-owned cats with chronic renal failure. PROCEDURES r-HuEPO was administered intravenously or subcutaneously. Erythropoietic(More)
OBJECTIVES To determine effects of commonly used diuretic treatments on glomerular filtration rate (GFR), renal blood flow (RBF), and urine output (UO) and compare 2 methods of GFR measurement in healthy awake cats. ANIMALS 8 healthy cats. PROCEDURE In a randomized crossover design, cats were randomly allocated to 4 groups: control; IV administration of(More)
Medical records of 137 dogs with protein-losing glomerular disease (PLGD) were evaluated. Cases with amyloidosis (23%) were more likely to be azotemic at presentation, with significantly greater proteinuria and hypoalbuminemia than those cases with glomerulonephritis (GN; 77%). The prognosis for all cases was poor, with a median survival time of just 28(More)
The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance.(More)
To investigate the role of parathyroid hormone (PTH) and(or) an intrinsic renal tubular reabsorptive defect for phosphate in mice with hereditary hypophosphatemic rickets, we performed clearance and micropuncture studies in hypophosphatemic mutants and nonaffected littermate controls. Increased fractional excretion of phosphate in mutants (47.2+/-4 vs.(More)