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This paper extends the theory of false discovery rates (FDR) pioneered by Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 57 (1995) 289–300]. We develop a framework in which the False Discovery Proportion (FDP)—the number of false rejections divided by the number of rejections—is treated as a stochastic process. After obtaining the limiting… (More)

- Han Liu, John D. Lafferty, Larry A. Wasserman
- Journal of Machine Learning Research
- 2009

Recent methods for estimating sparse undirected graphs for real-valued data in high dimensional problems rely heavily on the assumption of normality. We show how to use a semiparametric Gaussian copula—or “nonparanormal”—for high dimensional inference. Just as additive models extend linear models by replacing linear functions with a set of one-dimensional… (More)

Suppose we are analyzing data and we believe that the data arise from one of a set of possible models M1 , ..., Mk . In this paper, a model will refer to a set of probability distributions. For example, suppose the data consist of a normally distributed outcome Y and a covariate X and that two possibilities are entertained. The first possibility is that Y… (More)

We present a new class of methods for high-dimensional nonparametric regression and classification called sparse additive models (SpAM). Our methods combine ideas from sparse linear modeling and additive nonparametric regression. We derive an algorithm for fitting the models that is practical and effective even when the number of covariates is larger than… (More)

- Han Liu, Fang Han, Ming Yuan, John D. Lafferty, Larry A. Wasserman
- ICML
- 2012

In this paper, we propose a semiparametric approach, named nonparanormal skeptic, for efficiently and robustly estimating high dimensional undirected graphical models. To achieve modeling flexibility, we consider Gaussian Copula graphical models (or the nonparanormal) as proposed by Liu et al. (2009). To achieve estimation robustness, we exploit… (More)

- Shuheng Zhou, John D. Lafferty, Larry A. Wasserman
- Machine Learning
- 2008

Undirected graphs are often used to describe high dimensional distributions. Under sparsity conditions, the graph can be estimated using ℓ 1 penalization methods. However, current methods assume that the data are independent and identically distributed. If the distribution, and hence the graph, evolves over time then the data are not longer identically… (More)

We present a method for multiple hypothesis testing that maintains control of the False Discovery Rate while incorporating prior information about the hypotheses. The prior information takes the form of p-value weights. If the assignment of weights is positively associated with the null hypotheses being false, the procedure improves power, except in cases… (More)

- Larry A. Wasserman, Kathryn Roeder
- Annals of statistics
- 2009

This paper explores the following question: what kind of statistical guarantees can be given when doing variable selection in high dimensional models? In particular, we look at the error rates and power of some multi-stage regression methods. In the first stage we fit a set of candidate models. In the second stage we select one model by cross-validation. In… (More)

We present a new class of models for high-dimensional nonparametric regression and classification called sparse additive models (SpAM). Our methods combine ideas from sparse linear modeling and additive nonparametric regression. We derive a method for fitting the models that is effective even when the number of covariates is larger than the sample size. A… (More)