Larissa Melnikova

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BACKGROUND AND PURPOSE The goal of the present study was to investigate aging and genetic instability in the progeny of human fibroblasts exposed to X-rays and carbon ions. MATERIALS AND METHODS Following irradiation, cells were regularly subcultured until senescence. At selected time-points BrdU-labelling index, expression of cell cycle related proteins,(More)
To assess why during in vitro aging of fibroblasts the maintenance of chromosomal stability is effective or occasionally fails, a detailed cytogenetic analysis was performed in normal human IMR-90 fetal lung fibroblasts. The onset of senescence was inferred from proliferation activity, expression pattern of cell cycle regulating proteins, activity of(More)
Histone isolated from calf thymus inhibits the reproduction of DNA-containing vaccinia virus. F1 and F3 fractions of histone have the same effect though in a lesser degree than crude histone. F1 fraction has a stronger inhibitory effect than the F3 fraction. Inhibitory action of histone on the reproduction of vaccinia virus is principally attributed to the(More)
Introduction Former experiments have shown an increase in number of unstable chromosomal aberrations in normal human fibroblast strains with ongoing culturing time of the populations [1, 2]. These de novo formed unstable aberrations are an indicator of genomic instability which is considered to be one important step towards carcinogenesis. In the same(More)
Introduction Exposure of normal human fibroblasts to ionizing radiation may cause a delayed instability of the genome in the descendants of the initially irradiated cells [1, 2]. This genomic instability appears as a de novo formation of structural chromosomal aberrations and is considered as a step towards malignant transformation and induced(More)