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Hearts from AC8TG mice develop a higher contractility (LVSP) and larger Ca2+ transients than NTG mice, with (surprisingly) no modification in L-type Ca2+ channel current (ICa,L) (1). In this study,(More)
The beta-adrenergic cascade is severely impaired in heart failure (HF), in part because of a reduction in the activity of the two dominant cardiac adenylyl cyclase (AC) isoforms, AC5 and AC6. Hence,(More)
Evidence is provided that selection of the Chinese hamster cells CHLV-79 RJK with ethidium bromide results in amplification and overexpression of mdr family genes, one of which is encoding a(More)