Larisa G. Tereshchenko

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This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat QT interval variability (QTV) on surface electrocardiograms. The text covers measurement principles, physiological basis, and clinical value of QTV. Technical considerations include QT interval measurement and the relation between QTV and heart rate variability. Research(More)
BACKGROUND The clinical importance of the J-point elevation on electrocardiogram is controversial. OBJECTIVE To study intracardiac J-point amplitude before ventricular arrhythmia. METHODS Baseline 12-lead electrocardiogram and far-field right ventricular intracardiac implantable cardioverter-defibrillator electrograms were recorded at rest in 494(More)
BACKGROUND Methodological difficulties associated with QT measurements prompt the search for new electrocardiographic markers of repolarization heterogeneity. OBJECTIVE We hypothesized that beat-to-beat 3-dimensional vectorcardiogram variability predicts ventricular arrhythmia (VA) in patients with structural heart disease, left ventricular systolic(More)
BACKGROUND Arrhythmic sudden cardiac death (SCD) is generally mediated by ventricular fibrillation (VF) or fast ventricular tachycardia (FVT). We studied the predictive value of temporal QT variability detected from various sources of cardiac electric signal: surface ECG, far-field (FF), and near-field (NF) intracardiac electrograms (EGMs) in patients with(More)
BACKGROUND Recently we showed the predictive value of sum absolute QRST integral (SAI QRST) and repolarization lability for risk stratification of sudden cardiac death (SCD) in heart failure patients. The goal of this study was to compare SAI QRST and metrics of depolarization and repolarization variability in healthy men and women. METHODS Orthogonal(More)
BACKGROUND The goal of the present study was to determine the predictive value of beat-to-beat QT variability in heart failure patients across the continuum of left ventricular dysfunction. METHODS AND RESULTS Beat-to-beat QT variability index (QTVI), log-transformed heart rate variance, normalized QT variance, and coherence between heart rate variability(More)
BACKGROUND Current methods to identify patients at higher risk for sudden cardiac death, primarily left ventricular ejection fraction ≤35%, miss ≈80% of patients who die suddenly. We tested the hypothesis that patients with elevated QRS-scores (index of myocardial scar) and wide QRS-T angles (index abnormal depolarization-repolarization relationship) have(More)
PURPOSE The frequency, extent, time frame, and implications of changes to the modified early warning score (MEWS) in the 24 hours prior to cardiac arrest are not known. Our aim was to determine the prevalence and trends of the MEWS prior to in-hospital cardiac arrest (IHCA) on a ward, and to evaluate the association between changes in the MEWS and(More)
Invited Talk: Update on MD PnP program collaboration resources, Dr. Julian M. Goldman, MD. Dr. Goldman practices clinical anesthesia in the Massachusetts General Hospital Operating Room of the Future, serves as Medical Director of Partners HealthCare Biomedical Engineering, and leads the Medical Device Plug-andPlay Interoperability Program at the Center for(More)
BACKGROUND Monitoring arrhythmic risk may improve management of patients with implantable cardioverter-defibrillators (ICD) and prevent ICD shocks. Changes in repolarization duration between subsequent beats quantified as short-term variability (STV) is associated with ventricular arrhythmias in several animal models. OBJECTIVE We evaluated STV of QT from(More)