Larisa A. Panchenko

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In this work we examine how protein structural changes are coupled with sequence variation in the course of evolution of a family of homologs. The sequence-structure correlation analysis performed on 81 homologous protein families shows that the majority of them exhibit statistically significant linear correlation between the measures of sequence and(More)
We investigated the phenomenon of ultrasonic cleavage of DNA by analyzing a large set of cleavage patterns of DNA restriction fragments using polyacrylamide gel electrophoresis. The cleavage intensity of individual phosphodiester bonds was found to depend on the nucleotide sequence and the position of the bond with respect to the ends of the fragment. The(More)
Next Generation Sequencing (NGS) technology is based on cutting DNA into small fragments, and their massive parallel sequencing. The multiple overlapping segments termed "reads" are assembled into a contiguous sequence. To reduce sequencing errors, every genome region should be sequenced several dozen times. This sequencing approach is based on the(More)
We investigated a phenomenon of ultrasonic cleavage of DNA complexed with transition metal cations Ag(I), Cu(II) and Hg(II). We found the statistically significant dependence of relative intensity of cleavage on cation type and concentration. Each cation may cause two different types of distortion in the DNA double-helix depending on whether it binds to(More)
A method for studying the local inhomogeneities of DNA and its dynamics is proposed. The method is based on the combination of two procedures, splitting the DNA molecules by ultrasound and analysis of DNA fragments obtained by gel electrophoresis. The frequency of cleavage of internucleotide bonds was found to depend on the type of nucleotides forming the(More)
The course of alcoholic psychoses was juxtaposed to that of alcoholic beverages purchase in Moscow during 1984-1986. Antialcoholic measures since June, 1985, sharply decreased the number of psychoses to 33.1% of the 1984 level. Their distribution within a month has changed. The alcoholic beverages purchase in 1986 was 61.7% of that in 1984. The number of(More)
The survey includes data concerning structural proteins of coronaviruses obtained for the last ten years. It elucidates such problems as the proteins organization in the virion, heterogeneity of their composition, structure and biological properties, antigenic and immunobiological properties, prospects of creation of specific immunogenic anticoronavirus,(More)
Resistance to acute hypoxia in rats was evaluated by the life span after elevation to an altitude of 11,500 m at 13.00-21.00 (local time) in different seasons of one year. Geomagnetic activity was evaluated using local K index for Moscow and planetary Kp index. Total 24-h geomagnetic activity had a great impact on the life span of rats. The effects of local(More)