Lari Häkkinen

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Collagenase-3 (matrix metalloproteinase 13; MMP-13) is a novel matrix metalloproteinase, the expression of which to date has only been detected in human breast carcinoma tissue and osteoarthritic cartilage. Here, we show that MMP-13 transcripts are expressed by human HaCaT keratinocytes but not by primary human epidermal keratinocytes. The levels of MMP-13(More)
Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression or function promotes skin wound closure and granulation tissue(More)
Granulation-tissue fibroblasts are phenotypically unique cells that play an important role in wound repair and the development of chronic inflammatory lesions in connective tissue. In the present study, we compared proteoglycan, type I, and type III procollagen gene expression by granulation-tissue fibroblasts from wound and chronically inflamed tissues(More)
BACKGROUND Foetal nutrition and growth seem to affect the risk of developing schizophrenia. Exposure to famine during foetal development and low birthweight increase the risk. However, few studies have investigated the association between schizophrenia and adult height and weight or patterns of growth. METHOD The study population consisted of two(More)
Scar formation following skin injury can be a major psychosocial and physiological problem. However, the mechanisms of scar formation are still not completely understood. Previous studies have shown that wound healing in oral mucosa is faster, associates with a reduced inflammatory response and results to significantly reduced scar formation compared with(More)
BACKGROUND Previous studies suggest that offspring of mothers with psychotic disorders have an almost two-fold higher mortality risk from birth until early adulthood. We investigated predictors of mortality from late adolescence until middle age in offspring of mothers with psychotic disorders. METHOD The Helsinki High-Risk Study follows up offspring(More)
—In this work, source equivalence and computation of the reflected (induced) electromagnetic field in geophysical situations are studied. It is shown that the application of Huygens' principle allows for full generalization of Fukushima's equivalence theorem that applies only for magnetic field. The source equivalence is revisited for a vertical line(More)
Evolutionary lineages of Actinobacillus actinomycetemcomitans bear diverse traits to support roles as a member of normal flora and as a pathogen 1. Periodontitis 10 1.1 General characteristics and classification 10 1.2 Oral biofilms 10 1.3 Actinobacillus actinomycetemcomitans in periodontitis 12 2. Evolutionary lineages of A. actinomycetemcomitans 14 2.1(More)
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