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Salivary Blockade Protects the Lower Respiratory Tract of Mice from Lethal Influenza Virus Infection
ABSTRACT It is possible to model the progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the mouse using viral inoculum delivered in a restricted manner… Expand
Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity
The emergence of drug resistant variants of the influenza virus has led to a need to identify novel and effective antiviral agents. As an alternative to synthetic drugs, the consolidation of… Expand
Development of antiviral agents toward enterovirus 71 infection.
Enterovirus 71 (EV71) infection remains a public health problem at a global level, particularly in the Asia-Pacific region. The infection normally manifests as hand-foot-mouth disease; however, it is… Expand
Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach.
- K. Kirk, C. L. Poh, J. Fecondo, H. Pourianfar, J. Shaw, L. Grollo
- Medicine, Biology
- 19 November 2012
Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed… Expand
In vitro evaluation of the antiviral activity of heparan sulfate mimetic compounds against Enterovirus 71.
Enterovirus 71 (EV71) is the causative agent of hand foot and mouth disease (HFMD) and can also cause fatal neurological complications for which currently there is no vaccine or approved antiviral… Expand
Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine
- Babu Ramanathan, C. L. Poh, K. Kirk, W. McBride, J. Aaskov, L. Grollo
- Medicine, Biology
- PloS one
- 25 May 2016
Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human… Expand
A Colorimetric-Based Accurate Method for the Determination of Enterovirus 71 Titer
The 50 % tissue culture infectious dose (TCID50) is still one of the most commonly used techniques for estimating virus titers. However, the traditional TCID50 assay is time consuming, susceptible to… Expand
Initial evidence on differences among Enterovirus 71, Coxsackievirus A16 and Coxsackievirus B4 in binding to cell surface heparan sulphate
Cell surface heparan sulphate (HS) mediates infection for many viruses from diverse families. We demonstrated significant antiviral potencies for a number of HS mimetics against a cloned strain of… Expand
Evidence of Synergistic Activity of Medicinal Plant Extracts against Neuraminidase Inhibitor Resistant Strains of Influenza Viruses
The frequent emergence of drug resistant influenza viral strains emphasizes the urgent and continual need to develop new antiviral drugs. Given the encouraging findings of previous studies on… Expand
Global Impact of Heparin on Gene Expression Profiles in Neural Cells Infected by Enterovirus 71
Objectives: Heparan sulphate mimetics, particularly heparin (Hep), have previously been shown to considerably inhibit infection of enterovirus 71 (EV71) in Vero cells. Therefore, in this study, a… Expand