Lara C. Spencer

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Inoculation of the scarified cornea with herpes simplex virus (type 1) leads to herpetic infection of trigeminal ganglion cells. A recent study of the susceptibility of ganglion cells revealed that there may be at least four populations of trigeminal ganglion cells that are infectable by herpes. Two classes were identified by their neuropeptide content:(More)
Five distinct strong hydrogen-bonding interactions of four kinds (N-H...Cl, N-H...O, O-H...N, and O-H...Cl) connect molecules of the title compound, C(9)H(18)N(3)(+).Cl(-).H(2)O, in the crystal structure into corrugated sheets stacked along the a axis. The intermolecular interactions are efficiently described in terms of the first- through fifth-level graph(More)
Oligomers that contain both alpha- and beta-amino acid residues in a 1:1 alternating pattern have recently been shown by several groups to adopt helical secondary structures in solution. The beta-residue substitution pattern has a profound effect on the type of helix formed and the stability of the helical conformation. On the basis of two-dimensional NMR(More)
Oligomers containing both alpha- and beta-amino acid residues ("alpha/beta-peptides") are intriguing as potential foldamers. A large set of alpha/beta-peptide backbones can be generated by combining alpha- and beta-amino acid residues in different patterns; however, most research to date has focused on the simplest pattern, 1:1 alpha:beta. We have begun to(More)
The development of enantiomerically-resolved, axially-chiral seven-membered N-heterocyclic carbene ((7)NHC) ligands for palladium is described. These (7)NHC ligands are derived from enatiomerically pure 2,2'-diamino-6,6'-dimethylbiphenyl, which is transformed via a synthetic sequence consisting of ortho-arylation, N-alkylation, and cyclization to afford(More)
Covalent bond tables are used to generate hydrogen-bond pattern designator symbols for the crystallographically characterized title compounds. 2-(Pyrazol-1-yl)ethylammonium chloride, C(5)H(10)N(3)(+).Cl(-), (I), has three unique, strong, charge-assisted hydrogen bonds of the types N-H...Cl and N-H...N that form unary through ternary levels of graph-set(More)
In the title compound, [Li(C(8)H(16)O(4))(CD(3)CN)]ClO(4), the Li atom is penta-coordinate. The O atoms of the 12-crown-4 ether form the basal plane, whereas the N atom of the trideutero-aceto-nitrile occupies the apical position. The Li(+) atom is displaced by 0.794 (6) Å toward the apical position from the plane formed by the O atoms because the Li(+)(More)
Crystallographic analyses at 100 and 200 K are reported for the macrobicyclic polyether 4,7,13,16,21,24-hexaoxa-1,10-diaza-bicyclo[8.8.8]hexacosane (denoted as 222-cryptand) that encapsulates a Li+ cation and then forms a complex (I) with ClO4-. Compound (I) undergoes a reversible second-order k phase transition at 253 (2) K from an almost ordered structure(More)
In the title compound, [Au(2)(C(6)H(8)N(2)S(4))(C(18)H(15)P)(4)]·2CHCl(3), the digold complex resides on a crystallographic inversion center and co-crystallizes with two mol-ecules of chloro-form solvent. The piperazine-1,4-dicarbodithio-ate linker has an almost ideal chair conformation. The geometry about the gold atoms is severely distorted tetra-hedral(More)