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Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the opioid receptor-like-1 (ORL-1) orphan receptor, which is responsible for inhibition of delayed rectifier potassium current (I(K)). But its mechanism of N/OFQ acting on I(K) is not clear and whether PKC is involved in the modulation of this processing is still unknown. Whole-cell patch-clamp(More)
Nociceptin/orphanin FQ (N/OFQ) is an endogenous opioid-like heptadecapeptide involved in many neurocognitive functions, including learning and memory. Our previous report showed that N/OFQ inhibits the delayed rectifier potassium current (I(K)), and this effect is associated with protein kinase C (PKC) activation. Therefore, we wanted to determine if(More)
Diabetes mellitus is now fast emerging as one of the biggest health catastrophes the world has ever witnessed. It has huge global and societal implications, particularly in developing countries such as China and India [1]. China is now bring with it potential massive increase in type 1 diabetes (2-5% per annum increases in incidence in the world's most(More)
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