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BACKGROUND Hundreds of genes with differential DNA methylation of promoters have been identified for various cancers. However, the reproducibility of differential DNA methylation discoveries for cancer and the relationship between DNA methylation and aberrant gene expression have not been systematically analysed. METHODOLOGY/PRINCIPAL FINDINGS Using array(More)
Luteoloside is a potential anticarcinogenic component isolated from Lonicera japonica, a traditional Chinese medicine (TCM). This study details the development and validation of a sensitive and accurate HPLC-ESI-MS/MS method for the quantification of luteoloside in dog plasma. Sample pretreatment includes simple protein precipitation using(More)
BACKGROUND AND OBJECTIVE Survivin, a member of inhibitors of apoptosis protein (IAP) family, is expressed in most tumors as well as in different subcelluar units of tumors. This study was to investigate the clinical significance of survivin in different subcellular units in non-small cell lung cancer (NSCLC). METHODS The protein expression of survivin was(More)
This paper presents our system design for the Audio-Visual Emotion Challenge ($AV^{+}EC$ 2015). Besides the baseline features, we extract from audio the functionals on low-level descriptors (LLDs) obtained via the YAAFE toolbox, and from video the Local Phase Quantization from Three Orthogonal Planes (LPQ-TOP) features. From the physiological signals, we(More)
In the study, the kinetics of pressure-assisted solvent extraction (PSE) of polyphenols from green tea at different pressures (300, 400, 500 MPa) was studied. The model derived from Patricelli, which describes the two step extraction consisting of rapid washing followed by slow diffusion, had been applied to estimate the extraction kinetics. The model(More)
Based on microarray data, a basic task is to extract differentially expressed (DE) genes between disease states and their associated functions to understand disease mechanisms. However, few such analyses have been conducted for breast cancer metastasis, possibly owing to the uncertainty of the disease state assignment for patients, which may lead to an(More)
BACKGROUND Aberrant DNA methylation plays important roles in carcinogenesis. However, the functional significance of genome-wide hypermethylation and hypomethylation of gene promoters in carcinogenesis currently remain unclear. PRINCIPAL FINDINGS Based on genome-wide methylation data for five cancer types, we showed that genes with promoter(More)
In this paper, we present our system design for audio visual multi-modal depression recognition. To improve the estimation accuracy of the Beck Depression Inventory (BDI) score, besides the Low Level Descriptors (LLD) features and the Local Gabor Binary Pattern-Three Orthogonal Planes (LGBP-TOP) features provided by the 2014 Audio/Visual Emotion Challenge(More)
Desmoplastic small round cell tumors (DSRCTs) are extremely rare and mainly affect adolescents and young adults. The tumors are usually involved with the abdominal area and/or the pelvic peritoneum. Only a small number of cases have been reported concerning DSRCTs of the testicular region. The present study reports a case of DSRCT of the testis with radical(More)
How to extract bioactive compounds safely and efficiently is one of the problems for the food and pharmaceutical industry. In recent years, several novel extraction techniques have been proposed. To pursue a more efficient method for industrial production, high intensity pulsed electric field (HIPEF) extraction technique has been developed. HIPEF extraction(More)