Landon Berry

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There is increasing evidence that the supportive cells (stromal cells) in nearly all organs containing cellular self-renewal systems are involved in carcinogenesis. One body of evidence specific to irradiation leukemogenesis documents the role of irradiated murine stromal cells in the cell biologic changes associated with evolution of leukemia in(More)
D-type cyclins and cyclin-dependent kinase (cdk-4) are likely involved in regulating passage of cells through the G1 phase of the cell cycle. A decrease in the proportion of cells in G1, a relatively radiation-sensitive phase of the cell cycle, should result in increased resistance to ionizing radiation; however, the effect of such overexpression on(More)
Following 200 cGy total body irradiation, 20-25% of CBA/Ca mice and their CBA/B and CBA/H sublines develop myeloid leukemia. To determine whether hematologic changes in vitro were detectable, long-term marrow cultures (LTBMCs) were established from the right and left hind limbs of 11 individual control and 11 CBA/B mice 100-114 days after 200 cGy total body(More)
The role of bone marrow stromal cells of the hematopoietic microenvironment in ionizing-irradiation leukemogenesis is a focus of current investigation. Evidence from recent in vitro and in vivo experiments suggests that damage by slowly proliferating cells of the hematopoietic microenvironment contributes to the sustained survival of irradiation-damaged(More)
In vivo experiments have shown that hepatic steroid metabolism is under hormonal control but the intracellular mechanism of action of the hormones has been little studied. One pathway of hormone action known to be active in the liver is the alteration of cyclic-AMP levels. To investigate the role played by cyclic-AMP in the control of hepatic steroid(More)
The effects of various concentrations of cyclic AMP (cAMP) on the metabolism of androst-4-ene-3,17-dione were examined in electropermeabilized rat hepatocytes. cAMP had a biphasic effect on hepatic steroid metabolism which was dependent upon both concentration and time. At low concentrations (50 microM) early (1 h) inhibitory effects predominated, whereas(More)
This poster presentation will focus on the Surrealist logic behind a hand-coded website entitled "They'lI Ve," and how it can be combined with computer-mediated tools to create a collaborative invention space aimed at combating global or local issues. In particular, this presentation will demonstrate how the use of Surrealist logic can be used to create(More)
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