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The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes
With more chromosomes than any other sequenced genome, the macronuclear genome of Oxytricha trifallax has a unique and complex architecture, including alternative fragmentation and predominantly
Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate
TLDR
The yeast metabolic cycle is an intrinsic property of yeast metabolism and does not depend on either synchronization or external limitation of growth by the carbon source.
Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast
TLDR
A closer scrutiny of tumor suppressors with homopolymeric runs with proximal repeats as the potential drivers of oncogenesis in mismatch repair defective cells is suggested.
C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
TLDR
It is found that learning and short- and long-term memory can be distinguished, and that these processes share similar key molecules with higher organisms.
Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster.
TLDR
This study developed a novel strategy using chromosomal rearrangements and embryonic phenotypes to position unmapped Drosophila melanogaster heterochromatic sequence to specific chromosomal regions, and detects region-specific temporal patterns of transcription inheterochromatin during oogenesis and early embryonic development.
Extrachromosomal circular DNA is common in yeast
TLDR
It is proposed that eccDNAs may be precursors to the copy number variation in eukaryotic genomes characteristic of both the evolutionary process and cancer progression, and that they might contribute substantially to genetic variation and evolution.
Visualization and Analysis of mRNA Molecules Using Fluorescence In Situ Hybridization in Saccharomyces cerevisiae
TLDR
A protocol for using FISH to quantify the number of mRNAs in single yeast cells using multiple single-stranded deoxyoligonucleotides conjugated to fluorescent dyes to detect nucleic acids in the native cellular environment is provided.
Whole-Genome Sequence and Variant Analysis of W303, a Widely-Used Strain of Saccharomyces cerevisiae
TLDR
A high-quality, annotated genome sequence for W303 is provided for utilization in comparative analyses and genome-wide studies and variant mapping revealed more accurate identification of accumulated mutations in passaged mismatch repair-defective strains.
Bioconda: A sustainable and comprehensive software distribution for the life sciences
TLDR
A distribution of bioinformatics software for the lightweight, multi-platform and language-agnostic package manager, Conda, that improves analysis reproducibility by allowing users to define isolated environments with defined software versions.
Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae
TLDR
Recombination junctions are detected that are consistent with yeast Ty eccDNAs being generated through recombination events within the genome, opening the possibility that retrotransposable elements could move around in the genome without an RNA intermediate directly through DNA circularization.
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